Trial reportAesthetic plastic surgery2026
Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.
Trial report in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comments on "Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial".Aesthetic plastic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundClinical or experimental trials have shown that hydrogen-rich water has anti-inflammatory properties, but its use for keloids has not been studied. This research explores HRW's therapeutic potential and mechanism for keloid treatment.
methods21 keloid patients scheduled for two-stage operations were randomly divided into the HRW treatment group (HRW group) and the control group (Con group). The HRW group received hydrogen in their drinking water, while the Con group drank hydrogen-free water. Clinical information was collected. Cytokines related to inflammation, keloid formation, and symptoms were measured using western blotting (WB), qPCR, and ELISA before and after the interventions.
resultsPatients reported a significantly lower frequency of pain and pruritus after hydrogen-rich water therapy. The VSS and pigmentation domain scores significantly decreased after hydrogen-rich water therapy. WB and qPCR results showed a significant decrease in the expression of pruritus-related cytokine TRPV1 and keloid-related cytokine HIF-1α after hydrogen-rich water therapy. Anti-inflammatory cytokine IL-10 levels significantly increased after hydrogen-rich water therapy, while inflammation-related cytokines VEGF and TGF-β levels significantly decreased.
conclusionsHydrogen-rich water therapy appears to be a safe and promising approach for symptom relief and inflammation modulation in keloid patients. These findings represent an exploratory, double-blinded randomized pilot trial that provides early clinical signals supporting further large-scale investigation. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
41545661What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.