Evidence map›Paper›PMID 41545612›Full record

ArticleAnnals of surgical oncology2026

Tumor Laterality Predicts Pelvic Lymph Node Metastasis Patterns in Bladder Cancer.

Takahiko Hajime, Masaki Shiota, Genshiro Fukuchi, Jun Mutaguchi, Takashi Matsumoto, Tokiyoshi Tanegashima, Shigehiro Tsukahara, Satoshi Kobayashi, Masatoshi Eto

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takahiko HajimeDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masaki ShiotaDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. shiota.masaki.101@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0002-3306-4858
Genshiro FukuchiDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Jun MutaguchiDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takashi MatsumotoDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tokiyoshi TanegashimaDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shigehiro TsukaharaDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Satoshi KobayashiDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masatoshi EtoDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough lymph node involvement (LNI) is a critical prognostic factor guiding adjuvant therapy, randomized trials have failed to show a survival advantage of extended versus standard pelvic lymph node dissection (PLND) but have demonstrated increased morbidity. Refining PLND templates according to tumor characteristics, such as laterality, may improve the risk-benefit balance. This study aimed to clarify the relationship between bladder tumor location and the anatomical distribution of LNI in bladder cancer. PATIENTS AND

methodsWe retrospectively reviewed 102 patients who underwent radical cystectomy with bilateral extended PLND at Kyushu University Hospital between 2013 and 2024. Tumor laterality was classified as unilateral or bilateral. LNI sites were categorized as ipsilateral versus contralateral and by level (I: obturator, internal/external iliac; II: common iliac, presacral).

resultsOverall, 17.6% of patients had LNI. Bilateral tumors were associated with higher nodal metastasis than were unilateral tumors (24.2% vs. 14.5%). In unilateral tumors, contralateral LNI without ipsilateral involvement occurred in only 1.5% of cases. Level II metastasis was uncommon (5.9%), and skip metastasis to level II nodes without level I involvement was rare (1.0%).

conclusionsTumor laterality is a strong predictor of nodal distribution. The rarity of contralateral or skip metastasis warrants prospective studies to validate tailored, tumor location-based PLND strategies.

Indexed as

CystectomyLymph Node ExcisionLymph NodesPelvic NeoplasmsUrinary Bladder NeoplasmsAgedAged, 80 and overFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedPelvisPrognosisRetrospective StudiesLateralityLymph node involvementPelvic lymph node dissectionRadical cystectomyTumor location

Identifiers

PMID41545612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.