Evidence map›Paper›PMID 41545583›Full record

ArticleScientific reports2026

Environmental pollutants associated with blood glucose levels in healthy individuals.

Xuekui Liu, Gangshan Peng, Yanhong Lin, Wenruo Chen, Houfa Geng, Jun Liang

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuekui Liu *Department of Endocrinology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
Gangshan Peng *Department of Endocrinology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
Yanhong Lin *Xuzhou Medical University, Xuzhou Clinical Colleage, Xuzhou, Jiangsu, China.
Wenruo ChenXuzhou Medical University, Xuzhou Clinical Colleage, Xuzhou, Jiangsu, China.
Houfa GengDepartment of Endocrinology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, China. genghoufa@xzhmu.edu.cn.
Jun LiangXuzhou Medical University, Xuzhou Clinical Colleage, Xuzhou, Jiangsu, China. mwlj521@njmu.edu.cn.

Funding

Science and Technology Project of Xuzhou Municipal Health Commission 2025DF07the General Program of Jiangsu Provincial Preventive Medicine Research Project YM2023070
6 · The paper itself

Abstract

The occurrence of diabetes is closely linked to environmental pollution. In the pre-diabetic stage, the human body is actually already exposed to the environment. Exploring the correlation between environmental exposure substances and blood glucose levels in individuals with normal blood glucose is of great and positive practical significance for the effective prevention and precise control of diabetes. This study meticulously collected detailed information from 307 individuals in northern China, and sampled the serum of the participants for analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology. A total of 203 environmental exposure substances were detected. Results: Through in-depth exposome research, it was found that environmental exposure substances such as α-hexabromocyclododecane (α-HBCD), 4-methylbenzylidene camphor (4-MBC), and (1,2-diphenylethane-1,2-dione) benzil showed a significant positive correlation with the increase in blood glucose levels. In contrast, substances such as isopropylphenyl diphenyl disulfide (IPPD), tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), and dibenzothiophene sulfone (PES) were negatively correlated with blood glucose elevation. Both the Weighted Quantile Sum (WQS) analysis and the Bayesian Kernel Machine Regression (BKMR) analysis showed that there was a positive correlation between the overall effect of environmental exposure substances and blood glucose elevation (95% confidence interval = 1.141-1.721; P < 0.001). Environmental pollutants are important risk factors for the increase in blood glucose levels in healthy individuals. Moreover, these pollutants may interact with and affect each other, leading to a further rise in blood glucose levels.

Indexed as

Blood GlucoseEnvironmental ExposureEnvironmental PollutantsAdultChinaChromatography, LiquidFemaleHumansMaleMiddle AgedTandem Mass SpectrometryBlood GlucoseEnvironmental PollutantsBayesian kernel machine regressionEnvironmental pollutantsFasting plasma glucoseWeighted quantile Sum

Identifiers

PMID41545583
PMCPMC12891712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.