ArticleScientific reports2026
Children's state anxiety before MRI scanning and resting state functional connectivity in large scale brain networks.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionMost resting-state functional connectivity (rs-FC) research does not consider the participant’s subjective state during magnetic resonance imaging (MRI). Heightened anxiety before an MRI (“pre-scanning state anxiety”) may influence rs-FC and complicate interpretation of individual differences, particularly in underrepresented groups whose scanning experiences may differ from typical research samples.
methodsWe assessed associations between pre-scanning state anxiety and rs-FC within and between the default mode network (DMN) and salience network in a trait-anxious community sample of Latina girls (8–13 years) and a companion sample of treatment-seeking and healthy youth (8–18 years) of predominantly non-Latinx background. A constrained network-based statistical approach calculated the average of un-thresholded correlation coefficients from edge-level partial Spearman correlations to produce network-level measures (7 cortical + 1 subcortical). This approach is “constrained” in that analyses operate at the spatial scale of functional networks, rather than individual edges, to increase statistical power. Statistics were compared against a permutation-based null distribution to assess significance (Bonferroni corrected p < 0.00139).
resultsReduced rs-FC within the DMN (r = − 0.32, p < 0.00139) was associated with pre-scanning state anxiety in the community sample, but did not replicate in our companion sample. DISCUSSION: Pre-scanning state anxiety is associated with rs-FC within the DMN, but only among a trait-anxious community sample. Individual differences in MRI scanning experiences may be associated with rs-FC, but sample characteristics and replication should be considered.
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