Evidence map›Paper›PMID 41545418›Full record

ArticleNature communications2026

Spatiotemporally controlled drug release via a click-release system utilizing mono-alkyl-hydroxylamine and cyclooctyne chemistry.

Xiaowei Xu, Xidan Tong, Yangfei Shi, Xin Wang, Yanzhao Chen, Yuanan Wang, Mingxin Cheng, Shuanglong Chen, Hao Hao, Yan Liang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaowei Xu *State Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Xidan Tong *State Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Yangfei Shi *State Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Xin WangState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Yanzhao ChenState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Yuanan WangState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Mingxin ChengState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Shuanglong ChenState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Hao HaoState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Yan LiangState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China. liangyan@cpu.edu.cn.
Weiwei GuoSchool of Science, China Pharmaceutical University, Nanjing, PR China. guoweiwei@cpu.edu.cn.ORCID http://orcid.org/0000-0003-0387-7097
Yueqin ZhengState Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China. yzheng@cpu.edu.cn.ORCID http://orcid.org/0009-0004-8912-6044

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22377147
6 · The paper itself

Abstract

The advancement of bioorthogonal bond-breaking chemistry requires precise spatiotemporal control over chemical reactions. In this study, we introduce a click-release strategy based on the reaction between mono-alkyl-hydroxylamine and cyclooctyne (COT), enabling rapid and nearly complete payload release. We demonstrate that mono-alkyl-hydroxylamine and hydroxylamine react with COT to form nitrone and oxime, respectively, facilitating a versatile and efficient release mechanism. By conjugating mono-alkyl-hydroxylamine with responsive cleavable groups, we convert its inherent reactivity into an on-demand activation system. In vivo, this strategy is applied in a 4T1 mouse breast tumor model, showing significant tumor inhibition compared to the parent anticancer drug. Additionally, in local anesthesia, the anesthetic effect could be modulated by light exposure, allowing for repeated activation. This click-release system combines fast kinetics, high release efficiency, and precise spatiotemporal control, offering promising applications in chemical biology and drug delivery.

Indexed as

Antineoplastic AgentsClick ChemistryCyclooctanesDrug Delivery SystemsHydroxylamineAnimalsCell Line, TumorDelayed-Action PreparationsDrug LiberationFemaleMiceMice, Inbred BALB CNitrogen OxidesOximesAntineoplastic AgentsCyclooctanesDelayed-Action PreparationsHydroxylamineNitrogen OxidesnitronesOximes

Identifiers

PMID41545418
PMCPMC12917156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.