Evidence map›Paper›PMID 41545404›Full record

ArticleNature communications2026

Glutamatergic projection neurons in the basal forebrain underlie learned olfactory associational valence assignments.

Pey-Shyuan Chin, Zhuokun Ding, Mikhail Kochukov, Snigdha Srivastava, Elizabeth H Moss, Qingchun Tong, Benjamin R Arenkiel

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pey-Shyuan ChinDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Zhuokun DingDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Mikhail KochukovJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Snigdha SrivastavaJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Elizabeth H MossDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
Qingchun TongBrown Institute of Molecular Medicine at McGovern Medical School, University of Texas Health Science Center of Houston, Houston, TX, USA. Qingchun.Tong@uth.tmc.edu.ORCID http://orcid.org/0000-0002-4561-2540
Benjamin R ArenkielDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA. arenkiel@bcm.edu.ORCID http://orcid.org/0000-0001-9047-2420

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIORR01DK138518 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, YONG XU · 2024 to 2026
$1.9M
NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK138518U.S. Department of Defense (United States Department of Defense) PR22135
6 · The paper itself

Abstract

Sensory perception is shaped by experience, giving stimuli behavioral significance. Basal forebrain (BF) cholinergic neurons in mice, which are crucial for arousal and motivation, also regulate sensory processing. Within BF nuclei, glutamatergic (vGlut2

Indexed as

Basal ForebrainLearningNeuronsOlfactory PerceptionSmellAnimalsCholinergic NeuronsFemaleGlutamic AcidMaleMiceMice, Inbred C57BLOdorantsVesicular Glutamate Transport Protein 2Glutamic AcidVesicular Glutamate Transport Protein 2

Identifiers

PMID41545404
PMCPMC12905176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.