Evidence map›Paper›PMID 41545353›Full record

ArticleNature communications2026

Optimal murine CD4

Julia E Rood, Suh Kyung Yoon, Mary K Heard, Stephen D Carro, Emma J Hedgepeth, Mary E O'Mara, Michael J Hogan, Nhu Le, Hiromi Muramatsu, Kieu Lam and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Julia E RoodDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ROODJ@chop.edu.ORCID http://orcid.org/0000-0002-0755-8897
Suh Kyung YoonSchool of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0009-6258-6119
Mary K HeardDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Stephen D CarroDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Emma J HedgepethDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0005-8767-6402
Mary E O'MaraDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michael J HoganDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6244-2993
Nhu LeDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hiromi MuramatsuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1544-1493
Kieu LamGenevant Sciences Corporation, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-1965-5491
Petra SchreinerGenevant Sciences Corporation, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-8952-4748
Coral KasdenDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3320-5099
Hansell H StedmanDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2700-1815
Ryan A LangloisDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
James HeyesGenevant Sciences Corporation, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-9499-2028
Norbert PardiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1008-6242
Laurence C EisenlohrDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-8475-7910

Funding

Lipid nanoparticles as novel adjuvants inducing effective T follicular helper cell and humoral immune responsesR01AI153064 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michela Locci, Norbert Pardi · 2020 to 2026
$4.2M
Training Program/Rheumatic DiseasesT32AR076951 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI EDWARD M BEHRENS, Peter A Merkel · 2020 to 2026
$2.6M
NIAID NIH HHS R01 AI153064NIAMS NIH HHS T32 AR076951U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI153064
6 · The paper itself

Abstract

Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines elicit robust CD4

Indexed as

Antigen PresentationCD4-Positive T-LymphocytesLipidsNanoparticlesRNA, MessengerAnimalsAntigen-Presenting CellsFemaleHistocompatibility Antigens Class IILiposomesLymphocyte ActivationMiceMice, Inbred C57BLNanovaccinesHistocompatibility Antigens Class IILipid NanoparticlesLipidsLiposomesNanovaccinesRNA, Messenger

Identifiers

PMID41545353
PMCPMC12873236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.