ArticleJournal of the American Society for Mass Spectrometry2026
Continuous Flow Paper Spray Ionization Mass Spectrometry for In-Depth Characterization of Anticancer Drugs in Tissues: Addressing Mass Spectral Complexity.
Article in Journal of the American Society for Mass Spectrometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We introduced continuous flow paper spray ionization mass spectrometry (CFPSI MS) for the rapid detection and characterization of anticancer drugs in solid tissue samples. CFPSI is a paper spray-based semiquantitative method using continuous flow of an internal standard to quantify the amounts of drugs released from the tissue samples. Using patient-derived xenograft (PDX) mouse model tissue samples, we observed differential absorption of three anticancer drugs, palbociclib, copanlisib, and olaparib. Palbociclib was found to be bioabsorbed in the tissue samples to the largest extent. Tandem mass spectrometric analysis explored the in-source chemical reactivity of these drugs, leading to significant spectral complexity. Our findings highlight the importance of careful spectral interpretation in complex biological matrices and support the development of future rapid quantitative CFPSI analysis of these drugs in tissue samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.