SynthesisBirth defects research2026
The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation.
Synthesis in Birth defects research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation.Birth defects research · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundAdverse birth outcomes are important public health measures and account for a substantial public health burden. There is considerable diversity of these health endpoints, as well as in the many factors suspected or recognized to increase their risk. This diversity renders it challenging to synthesize the totality of the evidence by carrying out a systematic review.
methodsWe undertook an expert elicitation to characterize the state of the literature on this topic, the interconnections amongst risk factors, and identify those that are a priority for future research. A panel of 30 scientists and physicians with expertise in birth outcome epidemiology were solicited to identify a series of health outcomes, and associated risk factors.
resultsThis resulted in a listing of 15 birth outcomes, and 247 possible risk factors in total, with varying numbers of risk factors for each health outcome. Each panel member was asked to score the weight of evidence (WOE) of each risk factor and birth outcome combination (n = 1127) on a scale of 1 (no evidence) to 5 (strong evidence) for which the expert had a working knowledge of the literature. Not all experts scored each/every outcome/risk factor combination, reflecting the different types of expertise on the panel. The compilation of these WOE scores was used to create a publicly available database for birth outcomes risk factors (https://scipinion-rfbo.onrender.com) that is intended to be updated over time so as to serve as an up to date resource for the research and medical community.
conclusionsThis expert approach serves as a unique and valuable approach to data reduction that can help to inform research priorities, while providing an open access resource to identify risk factors that may act as confounders and/or modifiers in future epidemiology studies and clinical trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.