Evidence map›Paper›PMID 41544713›Full record

ArticleThe American journal of clinical nutrition2026

Biomarkers for dietary fatty acid densities among postmenopausal United States females derived using a habitual-diet human feeding study.

Ross L Prentice, Lesley F Tinker, Marian L Neuhouser, Johanna W Lampe, Daniel Raftery, Ga Nagana Gowda, Xiaoling Song, Sandi L Navarro, Ying Huang, Sowmya Vasan and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000611 (Women's Health Initiative), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000611 phase3completednot on this map

Women's Health Initiative (WHI)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)ConditionsBone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic NeoplasmsArmshormone replacement therapy, estrogens, progestins, estrogen replacement therapy, diet, fat-restricted
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA; Departments of Biostatistics and Epidemiology, School of Public Health, University of Washington, Seattle, WA. Electronic address: rprentic@whi.org.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA; Departments of Biostatistics and Epidemiology, School of Public Health, University of Washington, Seattle, WA.
Johanna W LampeDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA; Departments of Biostatistics and Epidemiology, School of Public Health, University of Washington, Seattle, WA.
Daniel RafteryDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle WA.
Ga Nagana GowdaDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle WA.
Xiaoling SongClinical Research Division, Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA.
Sandi L NavarroDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.
Ying HuangDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA; Departments of Biostatistics and Epidemiology, School of Public Health, University of Washington, Seattle, WA.
Sowmya VasanDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.
Tonya S OrchardDepartment of Human Sciences, Ohio State University, Columbus OH.
Theodore M BraskyDepartment of Internal Medicine, Ohio State University, Columbus OH.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA.
Cheng ZhengDepartment of Biostatistics, University of Nebraska Medical Center, Omaha NE.

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON · 1986 to 2026
$30.4M
Nutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3M
NCI NIH HHS R01 CA119171NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNIDA NIH HHS HHSN271201600004CNIDA NIH HHS HHSN271201600004INIDDK NIH HHS P30 DK035816
6 · The paper itself

Abstract

backgroundAlthough measures of blood and tissue fatty acid (FA) concentrations are available, objective measures of dietary FA densities (grams per kilocalories) are generally lacking.

objectivesWe aimed to explore the development of biomarkers for specific and composite dietary FA densities, not including contributions from dietary supplements, using metabolite profiles from serum and 24-h urine, along with separately measured serum phospholipid FA concentrations in the Women's Health Initiative.

methodsPotential biomarker equations were based on linear regression of feeding study dietary FA densities on metabolite concentrations, each log-transformed, among participants in a habitual-diet human feeding study (n = 153) within the Women's Health Initiative. Corresponding biomarker equations were also considered for total SFA, MUFA, and PUFA densities and for total n-3 and n-6 PUFA densities. Dietary FA density estimates derived from these equations were evaluated by correlation with feeding study intake densities, and by other important biomarker criteria.

resultsRegression cross-validated R

conclusionsCombinations of log-transformed metabolite concentrations can lead to objective intake density estimates for multiple FAs in the diets of United States postmenopausal females, with relevance to the reliable study of dietary FA densities and chronic disease risk. This study was registered at clinicaltrials.gov as NCT00000611 https://clinicaltrials.gov/study/NCT00000611).

Indexed as

DietDietary FatsFatty AcidsPostmenopauseAgedBiomarkersClinical Trials, Phase III as TopicFatty Acids, Omega-6Feeding BehaviorFemaleHumansMiddle AgedObservational Studies as TopicPhospholipidsRandomized Controlled Trials as TopicUnited StatesBiomarkersDietary FatsFatty AcidsFatty Acids, Omega-6Phospholipidsdietary biomarkerfatty acid densityphospholipid fatty acidserum metabolomicsurine metabolomics

Identifiers

PMID41544713
PMCPMC12975380

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.