Evidence map›Paper›PMID 41544621›Full record

ArticleGM crops & food2026

Comparative assessment of endogenous lipid transfer protein (LTP) level in genetically modified maize for its relevance in safety assessment.

Eric Ma, Saurabh Joshi, Ivan Birukou, Eric Rosenbaum

Abstract readComparative Study
In one paragraph

Article in GM crops & food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eric MaSeeds Product Safety, Syngenta Seeds, Durham, NC, USA.
Saurabh JoshiSeeds Product Safety, Syngenta Seeds, Durham, NC, USA.
Ivan BirukouSeeds Product Safety, Syngenta Seeds, Durham, NC, USA.
Eric RosenbaumSeeds Product Safety, Syngenta Seeds, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergenicity risk has been one of the safety concerns for genetically modified (GM) crops that are generated using modern biotechnologies. When there is the presence of endogenous allergens in a host crop, one question is often raised if genetic modification could increase their allergenicity risk. In this study, lipid transfer protein (LTP), the major endogenous allergen in maize, was measured and compared between various GM maize with their non-GM control as well as non-GM, commercial maize varieties. The results showed LTP levels have no meaningful difference in GM maize, and the LTP levels observed in GM maize were well encompassed within the potential natural variation range from non-GM maize varieties. Therefore, such endogenous LTP quantitation comparison in GM and non-GM control maize does not bring valuable information to the safety assessment of GM maize.

Indexed as

Carrier ProteinsPlant ProteinsPlants, Genetically ModifiedZea maysAllergensAntigens, PlantAllergensAntigens, PlantCarrier Proteinslipid transfer proteinlipid transfer proteins, plantPlant ProteinsAllergenicitygenetic modificationGMlipid transfer proteinLTPmaizerisk assessment

Identifiers

PMID41544621
PMCPMC12818802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.