Evidence map›Paper›PMID 41544538›Full record

ArticleInternational journal of hygiene and environmental health2026

Gestational PBDE concentrations and functional connectivity in adolescents: The HOME Study.

Jonathan Dudley, Kimberly Yolton, Alex D Edmondson, Yingying Xu, Aimin Chen, Jeffrey R Strawn, Joseph M Braun, Andreas Sjodin, Bruce P Lanphear, Kim M Cecil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan DudleyImaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Alex D EdmondsonImaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jeffrey R StrawnDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Andreas SjodinDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Bruce P LanphearDepartment of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Kim M CecilImaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: kim.cecil@cchmc.org.

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAU01AG088658 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Aimin Chen, Lifang Hou · 2024 to 2026
$6.5M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Longitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)R01ES031621 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, RYAN, PATRICK H · 2021 to 2025
$5.3M
Early life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1M
Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
NIA NIH HHS U01 AG088658NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES027224NIEHS NIH HHS R01 ES031621
6 · The paper itself

Abstract

backgroundGestational polybrominated diphenyl ethers (PBDE) exposure is linked with adverse neurobehavioral outcomes in children, but scientists do not fully understand how these flame retardants damage the developing brain.

objectiveWe estimated the association of gestational PBDE serum concentrations and intrinsic functional connectivity in 143 adolescents from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort enrolling from 2003 to 2006.

methodsWe measured maternal serum concentrations of five PBDE congeners and created a summary variable (∑

resultsHigher gestational BDE-153 serum concentrations were associated with higher local correlation in the left inferior lateral occipital cortex. Higher gestational PBDE serum concentrations (BDE-28, -47, -99, -100, and the ∑ DISCUSSION: Higher gestational PBDE serum concentrations were associated with diminished connectivity in the primary visual cortex. Connectivity patterns also mediated the relationship between gestational ∑

Indexed as

BrainEnvironmental PollutantsFlame RetardantsHalogenated Diphenyl EthersMaternal ExposurePrenatal Exposure Delayed EffectsAdolescentChildFemaleHumansMagnetic Resonance ImagingMalePregnancyProspective StudiesEnvironmental PollutantsFlame RetardantsHalogenated Diphenyl EthersAdolescentFunctional connectivityFunctional magnetic resonance imagingGestationalMediationPolybrominated diphenyl ether flame retardantsVisual cortex

Identifiers

PMID41544538
PMCPMC13151986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.