ArticleBlood advances2026
Platelet α-granule cargo packaging and endocytosis are important for normal mouse skin wound healing.
Article in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immuno-haemostatic dysregulation in heart failure with preserved ejection fraction.ESC heart failure · 2025Article
- Bacterial interactions with platelets: defining key themes.Frontiers in immunology · 2025Review
Corrections and comments
- Update of
Authors and funding
4 authors.
Funding
Abstract
abstractPlatelet-rich plasma or platelet-derived factors are often used to promote acute and chronic wound healing, an intricate, multistep process involving multiple cell types and factors. However, their use is controversial with mixed results, highlighting the need for detailed functional insights into how platelets affect wound healing beyond initial hemostasis. In this study, we investigated the importance of platelet function in physiological healing using a dorsal full-thickness excisional skin wound model in mice with defects in α-granule cargo packaging (Nbeal2-/- [neurobeachin-like 2 knockout] mice) and endocytic trafficking (platelet-specific Arf6-/- [ADP-ribosylation factor 6-deficient] and VAMP2/3Δ [vesicle-associated membrane protein 2/3-deficient] mice). Wound healing dynamics and skin structure, as established by histology, were significantly disrupted in all 3 mouse strains. Each showed unique kinetic, morphological, and structural healing patterns that differed from wild-type controls. Notably, Nbeal2-/- mice had delayed (epi)dermal regeneration, which was reflected by reductions in scab formation and/or resolution, re-epithelialization, and changes in cell migration and proliferation. In the platelet-specific endocytosis-deficient mice, Arf6-/- and VAMP2/3Δ, slower re-epithelialization was accompanied by defects in structural skin characteristics, including wound collagen and muscle/keratin content. Molecular profiling of bioactive peptides from skin (wound) extracts showed how modulating platelet α-granule cargo or endocytosis differentially affected healing, beyond initial hemostasis. Based on the changing profiles in the presence of several bioactive molecules (eg, interleukin-1β, vascular endothelial growth factor, matrix metalloproteinase 9, and tissue inhibitor of metalloproteinase 1), the inflammation, proliferation, and tissue remodeling phases all appear to be affected by platelet function(s). These findings provide a better understanding of platelets' role in all wound healing phases, thereby advancing clinical wound care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.