Evidence map›Paper›PMID 41544183›Full record

ArticleEmerging microbes & infections2026

Myxovirus resistance protein A to differentiate between viral and non-viral respiratory infections in adults: a prospective study.

Mengwei Yan, Nengyong Wang, Liping Yang, Xiaoqi Zhang, Yong Zhang, Weixia Xuan, Xiaoju Zhang, Gang Liu, Herong Wang, Yao Qing and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengwei YanCapital Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, New Cornerstone Science Laboratory, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Nengyong WangDepartment of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, People's Republic of China.
Liping YangDepartment of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, People's Republic of China.
Xiaoqi ZhangDepartment of Respiratory and Critical Care Medicine, Weifang Second People's Hospital, Weifang, People's Republic of China.
Yong ZhangDepartment of Respiratory and Critical Care Medicine, Weifang Second People's Hospital, Weifang, People's Republic of China.
Weixia XuanDepartment of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China.
Xiaoju ZhangDepartment of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China.
Gang LiuDepartment of Clinical Laboratory, Haihe Hospital, Tianjin University, Tianjin, People's Republic of China.
Herong WangDepartment of Respiratory and Critical Care, Haihe Hospital, Tianjin University, Tianjin, People's Republic of China.
Yao QingZybio Inc., Chongqing, People's Republic of China.
Yeming WangCapital Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, New Cornerstone Science Laboratory, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Bin CaoCapital Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, New Cornerstone Science Laboratory, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the diagnostic utility of Myxovirus resistance protein A (MxA) in differentiating between viral and non-viral respiratory infections in adults.

methodsThis prospective, multicenter diagnostic accuracy study enrolled adults with acute respiratory infections (ARI) from outpatient and inpatient settings, alongside asymptomatic controls. Peripheral blood was collected for quantitative MxA measurement. Pathogen detection used targeted next-generation sequencing combined with conventional microbiological testing. Aetiological diagnoses were determined using standardized algorithms based on detected pathogens. The diagnostic accuracy of MxA for identifying viral ARIs was calculated.

resultsAmong 518 ARI patients, 325 had viral pathogens detected, 131 had bacterial/fungal pathogens, and 62 had no pathogen detected. Median MxA levels were significantly higher in viral (123.6 ng/ml; interquartile range [IQR], 56.4-189.6) than bacterial/fungal infections (15.9 ng/ml; IQR, 9.9-38.1; Bonferroni test

conclusionsMxA demonstrates high diagnostic accuracy in distinguishing between viral and non-viral respiratory infections in adults.

Indexed as

Bacterial InfectionsMyxovirus Resistance ProteinsRespiratory Tract InfectionsVirus DiseasesAdultAgedDiagnosis, DifferentialFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMycosesProspective StudiesROC CurveSensitivity and SpecificityMX1 protein, humanMyxovirus Resistance ProteinsdiagnosticsinfluenzaMyxovirus resistance protein Arespiratory infectionsviral infection

Identifiers

PMID41544183
PMCPMC12818327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.