Evidence map›Paper›PMID 41544147›Full record

ArticleScience immunology2026

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages.

Ming-Ting Tsai, Ryann Callaghan, Charles Ng, Lisette Peres-Tintin, Dean B Matthews, Nikketa Stanford, Karuna Ganesh, Mary K Estes, Gretchen E Diehl

Abstract read
In one paragraph

Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ming-Ting TsaiMolecular Virology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3398-5083
Ryann CallaghanImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-2143-787X
Charles NgCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lisette Peres-TintinImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0003-3252-0553
Dean B MatthewsImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0000-4358-4892
Nikketa StanfordImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0003-2932-2337
Karuna GaneshMolecular Pharmacology Program, Sloan Kettering Institute, and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4948-1082
Mary K EstesDepartment of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4813-4249
Gretchen E DiehlImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-1841-2842

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Novel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and TopographyU19AI116497 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI ESTES, MARY KOLB · 2015 to 2025
$13.2M
Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions R01AI125264 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI GRETCHEN E DIEHL · 2017 to 2026
$4.1M
Mechanisms of Dynamic Transcriptional Reprogramming in Metastasis Stem CellsR37CA266185 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Karuna Ganesh · 2022 to 2026
$2.6M
Regulation of Microbial Trafficking to the Thymus in Early LifeF31AI183752 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Dean Matthews · 2024 to 2026
$149k
NCI NIH HHS P30 CA008748NCI NIH HHS R37 CA266185NIAID NIH HHS F31 AI183752NIAID NIH HHS R01 AI125264NIAID NIH HHS U19 AI116497NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Intestinal macrophages are essential for epithelial barrier repair. In homeostasis, macrophages are continuously replenished by recruitment of circulating C-C chemokine receptor 2 (CCR2)

Indexed as

Intestinal MucosaMacrophagesToll-Like Receptor 5AnimalsChemokine CCL2ColitisEscherichia coliFlagellinHumansIntestinal Barrier FunctionMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR2Signal TransductionCcr2 protein, mouseChemokine CCL2FlagellinReceptors, CCR2TLR5 protein, humanTlr5 protein, mouseToll-Like Receptor 5

Identifiers

PMID41544147
PMCPMC13016028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.