Evidence map›Paper›PMID 41544111›Full record

ArticlePLoS pathogens2026

Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages.

Kedišaletše Moloto, Mae Newton-Foot, Angela Dramowski, Stefany Ayala-Montaño, Ifeoluwa Akintayo, Andrew Whitelaw, Sandra Reuter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kedišaletše MolotoDivision of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.ORCID https://orcid.org/0000-0002-8360-6686
Mae Newton-FootDivision of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
Angela DramowskiDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stefany Ayala-MontañoInstitute for Infection Prevention and Control, Medical Center University of Freiburg, Freiburg, Germany.
Ifeoluwa AkintayoInstitute for Infection Prevention and Control, Medical Center University of Freiburg, Freiburg, Germany.
Andrew WhitelawDivision of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
Sandra ReuterInstitute for Infection Prevention and Control, Medical Center University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0003-1672-5789

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbapenem-resistant K. pneumoniae (CRKP) are increasingly prevalent pathogens in hospital settings worldwide. In early 2019, an outbreak of carbapenem-resistant Enterobacterales (CRE) at a tertiary hospital in South Africa triggered a retrospective investigation to determine local CRKP molecular epidemiology. The evolution of CRE at the institution progressed from sporadic cases in 2016-2017 to establishment of CRKP as an endemic pathogen by 2020. Of 778 clinical and carriage CRKP isolates (2016-2020), 413 (53%) were collected and sequenced. Sequence type (ST) 2621 (164, 40%) and ST39 (164, 40%) predominated with several minor STs making up the remainder. The majority of ST2621 associated with blaOXA-181 were isolated from adult patients (59%) and clinical samples (84%). ST39 with blaNDM-1 was predominantly identified in carriage isolates (76%) from neonatal (57%) and paediatric (38%) patients. The establishment of these unique CRKP clones distinct from the globally dominant epidemic lineages suggests local acquisition of carbapenemase genes with subsequent institutional propagation. Strengthening of infection prevention practices and antibiotic stewardship programmes at this institution is critical to reduce CRKP transmission and curtail evolution of future antimicrobial resistant clones.

Indexed as

Carbapenem-Resistant EnterobacteriaceaeCarbapenemsKlebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial Agentsbeta-LactamasesHumansMicrobial Sensitivity TestsRetrospective StudiesSouth AfricaTertiary Care CentersAnti-Bacterial Agentsbeta-LactamasesCarbapenems

Identifiers

PMID41544111
PMCPMC12810914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.