Evidence map›Paper›PMID 41544102›Full record

ArticlePancreas2026

Comprehensive Assessment of Direct and Passive Smoking Across the Pancreatitis Spectrum.

Samuel Han, Dhiraj Yadav, Jun Xu, Melena D Bellin, William E Fisher, Evan L Fogel, Chris Forsmark, Phil A Hart, Liang Li, Stephen J Pandol and 7 more

Abstract readMulticenter Study
In one paragraph

Article in Pancreas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Samuel HanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Dhiraj YadavDivision of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Jun XuDivision of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN.
Melena D BellinDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
William E FisherDepartment of Biostatistics, MD Anderson Cancer Center, Houston, TX.
Evan L FogelDepartment of Surgery, Baylor College of Medicine, Houston, TX.
Chris ForsmarkDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Indiana University, Indianapolis, IN.
Phil A HartDivision of Gastroenterology, Department of Internal Medicine, University of Florida, Gainesville, FL.
Liang LiDivision of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN.
Stephen J PandolDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Walter G ParkDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Guru TrikudanathanDepartment of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, CA.
Stephen K Van Den EedenDivision of Gastroenterology & Hepatology, Department of Internal Medicine, Stanford University, Stanford, CA.
Santhi Swaroop VegeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Darwin L ConwellDepartment of Research, Kaiser Permanente Northern California, Oakland, CA.
Christie Y JeonDepartment of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY.
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Funding

Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)U01DK108328 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Liang Li, Suyu Liu · 2015 to 2026
$32.8M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic CancerU01DK108300 · NIDDK · STANFORD UNIVERSITY · PI Sohail Z Husain, Walter Gwang-Up Park · 2015 to 2026
$6.3M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer (Admin Supplement)U01DK108288 · NIDDK · MAYO CLINIC ROCHESTER · PI Santhi Swaroop Vege · 2015 to 2026
$5.9M
The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCERU01DK108326 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FISHER, WILLIAM E · 2015 to 2024
$5.2M
U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERSU01DK108320 · NIDDK · UNIVERSITY OF FLORIDA · PI CUSI, KENNETH, FORSMARK, CHRISTOPHER E · 2015 to 2024
$4.6M
University of Minnesota Clinical Center for the Study of Pancreatic DiseaseU01DK126300 · NIDDK · UNIVERSITY OF MINNESOTA · PI GREGORY J BEILMAN, Melena D. Bellin · 2020 to 2026
$3.9M
Chronic Pancreatitis, Diabetes and Pancreatic Cancer: A Prospective ApproachU01DK108332 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI VAN DEN EEDEN, STEPHEN K. · 2015 to 2019
$1.9M
Ohio Kentucky Pancreatitis Research Center (OKPRC) to advance the diagnosis and treatment of chronic pancreatitisU01DK144496 · NIDDK · OHIO STATE UNIVERSITY · PI DARWIN LEWIS CONWELL, Zobeida Cruz-Monserrate · 2025 to 2026
$1.2M
NIDDK NIH HHS U01 DK108288NIDDK NIH HHS U01 DK108300NIDDK NIH HHS U01 DK108306NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01 DK108320NIDDK NIH HHS U01 DK108323NIDDK NIH HHS U01 DK108326NIDDK NIH HHS U01 DK108327NIDDK NIH HHS U01 DK108328NIDDK NIH HHS U01 DK108332NIDDK NIH HHS U01 DK126300NIDDK NIH HHS U01 DK144496
6 · The paper itself

Abstract

objectivesSmoking is a key risk factor for pancreatitis, contributing to pathogenesis and disease progression. Data regarding second-hand smoking, or passive smoking (PS) exposure, are lacking. We therefore aimed to assess the impact of PS exposure across the pancreatitis spectrum.

methodsWe analyzed baseline data from the PROCEED study, a multicenter study in the United States including patients with acute (AP), recurrent acute (RAP), and chronic (CP) pancreatitis. Participants detailed their individual smoking history and PS exposure, which was compared between AP, RAP, and CP subgroups. Participant factors and clinical characteristics were compared by level of individual and PS exposure.

resultsAmong 1369 participants (190 AP, 498 RAP, 681 CP), 346 (25.3%) were current and 409 (29.9%) were former smokers. The CP subgroup had the highest proportion of current smokers (36.7% CP vs 15.1% RAP, 11.1% AP, P < 0.001). PS exposure was also significantly higher in the CP subgroup (68.6% CP vs 58.2% RAP, 55.3% AP, P < 0.001). A minority (16.3%) with CP reported no smoking exposure (by self or passive) while nearly half smoked ≥20 pack-years. The mean PS duration was significantly higher in CP participants (21.8 y) compared with those with AP (17.8 y) or RAP (18.9 y) ( P < 0.0166).

conclusionsIn this multicenter study, we affirmed an association with smoking use and intensity with CP-related complications. For the first time, we report a high prevalence of prior exposure to passive smoking in all pancreatitis subtypes, which requires further study to understand the impact on disease outcomes.

Indexed as

PancreatitisPancreatitis, ChronicSmokingTobacco Smoke PollutionAcute DiseaseAdultAgedFemaleHumansMaleMiddle AgedRecurrenceRisk FactorsUnited StatesTobacco Smoke Pollutionacute pancreatitisacute recurrent pancreatitischronic pancreatitispassive smokingsecond-hand smokingsmoking

Identifiers

PMID41544102
PMCPMC13222071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.