Evidence map›Paper›PMID 41544016›Full record

ArticlePloS one2026

Preparation and in vivo effectiveness evaluation of heparin-loaded PLGA@PCL core-shell fiber small-diameter vascular grafts.

Yonghao Xiao, Han Wang, Yuhao Jiao, Yuehao Xing, Lin Ye, Ai-Ying Zhang, Xue Geng, Fanshan Qiu, Zengguo Feng, Hongbo Chen and 1 more

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yonghao XiaoCollege of Light Industry Science and Engineering, Tianjin University of Science and Technology, Tianjin, China.ORCID https://orcid.org/0000-0002-7402-9012
Han WangSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.ORCID https://orcid.org/0000-0001-5102-2400
Yuhao JiaoDepartment of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijin, China.
Yuehao XingDepartment of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijin, China.
Lin YeSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.
Ai-Ying ZhangSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.
Xue GengSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.
Fanshan QiuNational Institute for Food and Drug Contro University, Beijing, China.
Zengguo FengSchool of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.
Hongbo ChenNational Institute for Food and Drug Contro University, Beijing, China.
Yongquan GuDepartment of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease has become the leading cause of death. It is the common goal for researchers worldwide to develop small-diameter vascular grafts (SDVGs) which could meet clinical needs. In this study, PLGA@PCL core-shell structural fibrous SDVGs was fabricated by coaxial electrospinning process, and then the surface heparinization of the vascular material was carried out after H2N-PEG-NH2 fixed on sodium hydroxide-treated electro-spun PCL tubes. Finally, the long-term patency and tissue regeneration of the grafts were evaluated in vivo through the rabbit carotid artery replacement model. The results indicate that the heparin-modified PLGA@PCL core-shell structural fibrous SDVGs achieved long-term patency and the arrangement of collagen and elastin in the neointima was similar to the native vessel in the rabbits after 9 months. After 3 months postoperatively, endothelialization was almost complete, and vascular calcification was also observed. It can be concluded that surface heparinization is a feasible modification method for in situ tissue-engineered vascular grafts, and controlling the occurrence of vascular calcification is another important issue to be solved in the development of SDVGs, and it is also the focus of our next research work.

Indexed as

Blood Vessel ProsthesisHeparinLactic AcidPolyestersPolyglycolic AcidAnimalsCarotid ArteriesMalePolylactic Acid-Polyglycolic Acid CopolymerRabbitsTissue EngineeringVascular PatencyHeparinLactic AcidpolycaprolactonePolyestersPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID41544016
PMCPMC12810837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.