ArticleCardiology2026
Inflammatory Bowel Disease Is Associated with Pericarditis: A Cross-Sectional Study in an NIH-Sponsored, Nationwide Database.
Article in Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionInflammatory bowel disease (IBD) is a chronic inflammatory condition affecting approximately 2.39 million individuals in the USA. IBD is associated with extraintestinal manifestations (EIMs), among which pericarditis is prominent, comprising 70% of cardiac EIMs. The onset of pericarditis in these patients is primarily attributed to IBD medication-related adverse effects and is predominantly documented through case reports. This highlights the need for an epidemiological study in a large, propensity-matched cohort, given the significant morbidity and mortality of pericarditis.
methodsUsing the National Institutes of Health's (NIH) All of Us Research Program, we conducted a cross-sectional study and propensity-matched 5,178 IBD cases to 15,534 controls (1:3). We compared demographics, clinical characteristics, prevalence of autoimmune diseases, and rates of pericarditis. Logistic regressions assessed the association between IBD and pericarditis, adjusting for confounders (p < 0.15), and a sensitivity analysis confirmed the association (p < 0.001). A Kaplan-Meier analysis compared the incidence of pericarditis in various IBD severity cohorts, including mild (n = 620) and moderate/severe (n = 1,908), stratified by IBD medication exposure.
resultsPericarditis was significantly more prevalent in IBD cases (1.3% vs. 0.6%; absolute risk difference 0.7%, 95% confidence interval [CI]: 0.37%-1.03%), with significant associations in univariable (odds ratio [OR] 2.2, 95% CI: 1.6-3.0, p < 0.001) and multivariable (OR 1.9, 95% CI: 1.3-2.6, p < 0.001) analyses. IBD preceded pericarditis in 65% of cases. There was no difference in pericarditis-free survival between mild and moderate/severe cohorts (p = 0.90).
conclusionThis study uniquely provides evidence of a significant association between IBD and pericarditis, establishing pericarditis as a clinically significant EIM in a large, diverse US cohort, independent of disease severity. This highlights the need for heightened screening to enhance pericarditis management and patient outcomes.
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