Evidence map›Paper›PMID 41543922›Full record

ArticleJournal of medicinal chemistry2026

SH2

Luis M Gonzalez Lira, Jennifer K Wolfe-Demarco, Alexander M Clifford, Tuan D Le, Ghadeer M Khasawneh, Medhanie Kidane, Michelle Nguyen, Julia A Najera, Gabriel Pallares, Nicole B Servant and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Luis M Gonzalez LiraEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Jennifer K Wolfe-DemarcoEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Alexander M CliffordEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Tuan D LeEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Ghadeer M KhasawnehEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Medhanie KidaneEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Michelle NguyenEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Julia A NajeraEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Gabriel PallaresEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Nicole B ServantEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.
Jean A BernatchezEurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States.ORCID 0009-0005-3263-4109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug discovery targeting SH2 domains (key protein-protein interaction modules) has been hampered by a lack of assay systems evaluating synthetic ligand binding selectivity toward SH2 domains to reduce potential off-target effects. In addition, the molecular determinants for the synthetic ligand engagement to SH2 domains across the target class have yet to be defined. Here, we developed SH2

Indexed as

src Homology DomainsDrug DiscoveryHigh-Throughput Screening AssaysHumansLigandsProtein BindingLigands

Identifiers

PMID41543922
PMCPMC12951562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.