Evidence map›Paper›PMID 41543902›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Chemical tuning reveals a cation-π gating bridge between the voltage-sensor and pore domains in the K

Miranda E Schene, Christopher A Ahern

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miranda E ScheneDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa, IA 52245.ORCID 0000-0002-5653-543X
Christopher A AhernDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa, IA 52245.ORCID 0000-0002-7975-2744

Funding

Chemical biology of voltage-gated cation channelsR35GM148239 · NIGMS · UNIVERSITY OF IOWA · PI Christopher A Ahern · 2023 to 2026
$2.5M
Using a Molecular Toolkit to Examine Potassium Channel Gating and RegulationF30HL165692 · NHLBI · UNIVERSITY OF IOWA · PI SCHENE, MIRANDA · 2022 to 2025
$178k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F30HL165692HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35148239NIGMS NIH HHS R35 GM148239
6 · The paper itself

Abstract

K

Indexed as

Ion Channel GatingKCNQ1 Potassium ChannelAnimalsCationsCryoelectron MicroscopyHumansModels, MolecularMutationProtein DomainsCationsKCNQ1 Potassium Channelgenetic code expansionion channel structure and gatingmembrane proteinsprotein engineering

Identifiers

PMID41543902
PMCPMC12818427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.