Evidence map›Paper›PMID 41543792›Full record

ArticleInflammation2026

A Novel YTHDF2/SIGMAR1 Axis in Astrocytes Regulates Neuroinflammation and Cognitive Impairment in Diabetic Encephalopathy.

Feng Xu, Hao Zhang, Xiaohong Chen, Chengwei Duan, Qiuyue Gu, Ji Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Feng XuDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China. xufeng5205529@163.com.
Hao Zhang *Intensive Care Unit, Nantong Hospital of Traditional Chinese Medicine, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, Nantong, China.
Xiaohong Chen *Department of Endocrinology, Nantong First People's Hospital, Affiliated Nantong Hospital of Southeast University, Nantong, China.
Chengwei DuanMedical Research Center, Nantong First People's Hospital, Affiliated Nantong Hospital of Southeast University, Nantong, China.
Qiuyue GuDepartment of Endocrinology, Nantong First People's Hospital, Affiliated Nantong Hospital of Southeast University, Nantong, China.
Ji HuDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China. huji@suda.edu.cn.

Funding

Nantong Municipal Health Commission MS2024043Nantong Science and Technology Bureau MSZ2024019National Natural Science Foundation of China 82170836Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD050710Sub-projects of National Science and Technology Major Project 2023ZD0507103
6 · The paper itself

Abstract

Diabetic encephalopathy (DE), a severe complication of diabetes, is characterized by cognitive decline and neuroinflammation, in which astrocytes play a critical role. YTHDF2, an m

Indexed as

AstrocytesBrain DiseasesCognitive DysfunctionDiabetes ComplicationsNerve Tissue ProteinsNeuroinflammatory DiseasesRNA-Binding ProteinsAnimalsHypoglycemiaMaleMiceMice, Inbred C57BLNerve Tissue ProteinsRNA-Binding ProteinsYTHDF2 protein, mouseAstrocyte activationDiabetic encephalopathyInflammationN6-methyladenosineYTHDF2

Identifiers

PMID41543792
PMCPMC12882864

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.