Evidence map›Paper›PMID 41543685›Full record

ReviewBiological trace element research2026

Natural Defenses Against Cadmium Toxicity: Mechanisms and Emerging Strategies - A Review.

Lukman Iddrisu, Linru Huang, Evodia Moses Mkulo, Felix Danso, Derrick Asare, Adam Salifu, Zhijia Fang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lukman Iddrisu *College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology, Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Guangdong Ocean University, Zhanjiang, 524088, China.
Linru Huang *College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology, Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Guangdong Ocean University, Zhanjiang, 524088, China.
Evodia Moses MkuloCollege of Fisheries, Guangdong Ocean University, Zhanjiang, China.
Felix DansoDepartment of Veterinary Medicine, Guangdong Ocean University, Zhanjiang, 524088, China.
Derrick AsareCollege of Fisheries, Guangdong Ocean University, Zhanjiang, China.
Adam SalifuDepartment of Biodiversity and Ecosystem Management, Route Kasapa, University of Lubumbashi, BP 1825, Lubumbashi, Democratic Republic of the Congo.
Zhijia FangCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology, Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Guangdong Ocean University, Zhanjiang, 524088, China. fzj4437549@163.com.

Funding

Guangdong Basic and Applied Basic Research Foundation 2021A1515012443National Natural Science Foundation of China 32172215Special Project of Science and Technology Development of Zhanjiang 2022A01014
6 · The paper itself

Abstract

Cd is a ubiquitous and toxic heavy metal, characterized by environmental persistence and bioaccumulation, which presents high risks to agricultural production and human health. In this review, natural countermeasures against Cd toxicity are systematically categorized into inorganic substances, active natural products, and microorganisms. We discuss these compounds as protectants and the shared and distinct mechanisms by which they reduce metal toxicity, including competitive uptake, chelation, antioxidant enhancement, and gene regulation. A comprehensive review of studies published in recent years highlights the great influence on protective efficacy by compound-specific mechanisms, including the role of essential metals in competitive uptake and induction of particular antioxidant pathways through phyto-chemical exposure. Despite this, major knowledge gaps are still left to be filled, especially concerning the combined impact of treatments and their performances under field conditions or long-term sustainability. The aim of the present study is to explain the mechanisms for their protective effects, and these results offer an overview to contribute to developing environmentally friendly methods for Cd phytoremediation. This literature review comprehensively summarizes the up-to-date comprehension of natural protection against Cd, and will provide an insight for the subsequent investigations on the practical applications in agriculture, environmental treatment, and public health to ensure food system safety and land reduction of pollutants from the contaminated environment.

Indexed as

Biological ProductsCadmiumAntioxidantsBiodegradation, EnvironmentalHumansAntioxidantsBiological ProductsCadmiumAlleviation mechanismAmino acidsCadmium stressExogenous compoundsOrganisms

Identifiers

PMID41543685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.