ArticleInternational archives of occupational and environmental health2026
Mediating role of metabolic dysfunction-associated fatty liver disease in the association between individual-level noise exposure and liver enzymes in Chinese automotive manufacturing workers.
Article in International archives of occupational and environmental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLimited research has explored the relationship between occupational noise exposure and liver enzymes, particularly at the individual exposure level. This study examines the association between occupational noise exposure and liver enzyme levels and the mediating role of metabolic dysfunction-associated fatty liver disease (MAFLD).
methodsWe recruited 3,427 workers from two factories in Guangzhou, China. Cumulative noise exposure (CNE) was estimated based on noise levels and years of exposure. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase (GGT) levels were obtained from medical examinations. Linear and logistic regression models, along with subgroup and mediation analyses, were employed to assess the associations between CNE and liver enzyme levels.
resultsCumulative noise exposure (CNE) demonstrated a dose-response relationship with liver health indicators, with significant associations observed across different statistical models. Specifically, each 10 dB(A)-year increase in CNE was associated with a 2.10 U/L increase in ALT levels and a 26% higher risk of elevated ALT. Concurrently, categorical models revealed that workers in the highest CNE group had significantly increased risks of elevated ALT, AST, and GGT, with the most pronounced effect observed for AST. These associations were significantly strengthened by insufficient physical activity (P
conclusionOccupational noise exposure is positively associated with liver enzymes, with MAFLD as a partial mediator. Noise control measures and liver function monitoring may help mitigate liver dysfunction.
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