Evidence map›Paper›PMID 41543587›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Pediatric intracranial inflammatory myofibroblastic tumor harboring DCTN1::ALK fusion: a case report with radiologic-pathologic-molecular correlation.

Ali Jama Ali, Qiang Li, Chengyuan Dong

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ali Jama AliDepartment of Neurosurgery, West China Hospital of Sichuan University, No.37 Guoxue Road, Chengdu, 610041, P.R. China.ORCID 0009-0002-8643-7184
Qiang LiDepartment of Neurosurgery, West China Hospital of Sichuan University, No.37 Guoxue Road, Chengdu, 610041, P.R. China. baruud113@gmail.com.
Chengyuan DongDepartment of Neurosurgery, West China Hospital of Sichuan University, No.37 Guoxue Road, Chengdu, 610041, P.R. China.ORCID 0000-0002-5430-5091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous system inflammatory myofibroblastic tumors are rare; pediatric DCTN1::ALK fusion cases are exceptionally uncommon. Here, we present an eight-year-old boy who presented with headache, vomiting, and a rapidly enlarging right frontal scalp mass. An MRI showed a dural, extra-axial lesion with mass effect. Histology confirmed IMT, and ALK immunohistochemistry was positive; next-generation sequencing (NGS) identified DCTN1 (exon 1-27)-ALK (exon 20-29) fusion, and FISH confirmed ALK rearrangement (33/100 nuclei). Genomic metrics showed tumor mutational burden (TMB) of 0.94/Mb, microsatellite stability, and CNV burden of 2.1%. He underwent near total resection followed by alectinib; to our knowledge, this is the first reported young pediatric (<10 years old) CNS IMT with this fusion.

Indexed as

Anaplastic Lymphoma KinaseBrain NeoplasmsDynactin ComplexNeoplasms, Muscle TissueChildHumansMagnetic Resonance ImagingMaleALK protein, humanAnaplastic Lymphoma KinaseDCTN1 protein, humanDynactin ComplexCentral nervous systemDCTN1::ALKGene fusionInflammatory myofibroblastic tumorPediatric

Identifiers

PMID41543587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.