Evidence map›Paper›PMID 41543389›Full record

ArticlePhysiological genomics2026

Systems genomics reveals age- and sex-dependent metabolic dysregulation from

Ingrid Cely, Montgomery Blencowe, Le Shu, Graciel Diamante, In Sook Ahn, Guanglin Zhang, Jonnby LaGuardia, Ruoshui Liu, Owen Briscoe, Zara Saleem and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ingrid CelyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Montgomery BlencoweDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.ORCID 0000-0001-7147-1895
Le ShuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Graciel DiamanteDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
In Sook AhnDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Guanglin ZhangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Jonnby LaGuardiaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.ORCID 0000-0001-7661-9035
Ruoshui LiuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Owen BriscoeDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Zara SaleemDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Susanna WangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.
Richard C DavisDepartment of Medicine, University of California, Los Angeles, California, United States.
Hongxiu QiDepartment of Medicine, University of California, Los Angeles, California, United States.
Aldons J LusisDepartment of Medicine, University of California, Los Angeles, California, United States.ORCID 0000-0001-9013-0228
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, United States.ORCID 0000-0002-3971-038X

Funding

Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Systems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
HHS | National Institutes of Health (NIH) DK 104363HHS | National Institutes of Health (NIH) DK117850HHS | National Institutes of Health (NIH) HL147883NHLBI NIH HHS R01 HL147883NIDDK NIH HHS R01 DK104363NIDDK NIH HHS R01 DK117850
6 · The paper itself

Abstract

Glyoxalase 1 (Glo1) detoxifies reactive dicarbonyl compounds such as methylglyoxal, a precursor of advanced glycation end products (AGEs), which contribute to metabolic disorders. However, the contribution of AGE-independent mechanisms to

Indexed as

AgingGenomicsLactoylglutathione LyaseAnimalsFemaleGlycation End Products, AdvancedLipid MetabolismMaleMicePhenotypePyruvaldehydeSex CharacteristicsSex FactorsGlo1 protein, mouseGlycation End Products, AdvancedLactoylglutathione LyasePyruvaldehydeadvanced glycation endproductsglyoxalase 1metabolic syndromeobesitysex difference

Identifiers

PMID41543389
PMCPMC12928164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.