Evidence map›Paper›PMID 41543363›Full record

ArticleMolecular nutrition & food research2026

Association Between the Dutch Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND-NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study.

Sonja Beers, Lisette C P G M de Groot, Mark R van Loenen, Lianne B Remie, Mechteld Grootte Bromhaar, Andrea Anesi, Urska Vrhovsek, Joukje M Oosterman, Esther Aarts, Mara P H van Trijp and 1 more

Abstract read
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In one paragraph

Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sonja BeersDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Lisette C P G M de GrootDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Mark R van LoenenRadboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Lianne B RemieRadboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Mechteld Grootte BromhaarDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Andrea AnesiUnit of Metabolomics, Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach (FEM), San Michele all'Adige, Italy.
Urska VrhovsekUnit of Metabolomics, Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach (FEM), San Michele all'Adige, Italy.
Joukje M OostermanRadboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Esther AartsRadboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Mara P H van TrijpDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Yannick VermeirenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.

Funding

Dutch Research Council
6 · The paper itself

Abstract

Tryptophan (TRP) metabolism is emerging as a focus of investigation in Alzheimer's disease research. In addition, diet might impact TRP's metabolic fate. The aim of this study was to explore the association between adherence to the Dutch Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND-NL) diet and systemic TRP metabolite levels and their related ratios in older adults at risk of cognitive decline. Data of the HELI multidomain lifestyle intervention study (n = 82) were used. Dietary intake data (FFQ) and fasted plasma levels were collected at baseline and 26 weeks follow-up. Bivariate Latent Change Score Models (LCSMs) were applied to assess both level-level and change-change associations, adjusted for lifestyle factors. Changes in MIND-NL diet adherence were significantly inversely associated with changes in the kynurenine:large neutral amino acids ratio (path coefficient -0.457, SE:0.206, p = 0.03) and kynurenine:tryptophan ratio (path coefficient -0.558 SE:0.235, p = 0.02). In addition, MIND-NL diet adherence was associated with lower levels of the neurotoxic metabolite quinolinic acid (path coefficient -0.186, SE:0.0700, p = 0.008), but within the crude model only. Our findings suggest that greater adherence to the MIND-NL diet may contribute to decreased activation of the kynurenine pathway.

Indexed as

Cognitive DysfunctionDietary Approaches To Stop HypertensionDiet, MediterraneanTryptophanAgedFemaleHumansKynurenineMaleMiddle AgedNetherlandsNeurodegenerative DiseasesPatient ComplianceKynurenineTryptophandietary patternkynurenine pathwaylatent change modelserotonin

Identifiers

PMID41543363
PMCPMC12810439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.