ArticleExperimental physiology2026
Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long-duration spaceflight.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long-duration spaceflight.Experimental physiology · 2026Article
- Beyond intracranial pressure: Cerebrospinal fluid compartmentalization in spaceflight-associated neuro-ocular syndrome.Experimental physiology · 2026Article
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20 authors.
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Abstract
Long-duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight-associated neuro-ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars missions. Concurrently, spacefarers experience brain adaptations, including ventricular expansion and CSF redistribution; however, the integrative physiological mechanisms linking these brain-eye responses remain unestablished. We applied automated morphometric analysis to investigate brain-eye relationships using high-resolution MRI data from terrestrial control subjects and spacefarers, conducting correlation analysis between third ventricle volume and ocular parameters. Analysis revealed significant baseline correlations between third ventricle volume and multiple ocular parameters in healthy control subjects, including globe dimensions, optic nerve sheath volume, optic nerve length and retro-orbital width. Following spaceflight, adaptations occurred: optic nerve sheath volume increased by 11.93 ± 6.07 mm
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