Evidence map›Paper›PMID 41543281›Full record

ArticleACS infectious diseases2026

Substrate Specificity Checkpoints of the Multidrug Efflux Pump MexF from

Muhammad R Uddin, Silvia Gervasoni, Giuliano Malloci, Paolo Ruggerone, Helen I Zgurskaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad R UddinDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.
Silvia GervasoniDepartment of Physics, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0002-5731-3396
Giuliano MallociDepartment of Physics, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Paolo RuggeroneDepartment of Physics, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.ORCID 0000-0001-8929-4727

Funding

Transport across two membranes by AcrAB-TolC complexR01AI052293 · NIAID · UNIVERSITY OF OKLAHOMA NORMAN · PI ZGURSKAYA, HELEN I · 2003 to 2024
$7.7M
Atlas of efflux and permeation determinants to advance antibacterial therapeutic discoveryR01AI191767 · NIAID · UNIVERSITY OF OKLAHOMA · PI VALENTIN V RYBENKOV, John K. Walker · 2025 to 2026
$2.2M
NIAID NIH HHS R01 AI052293NIAID NIH HHS R01 AI191767
6 · The paper itself

Abstract

Multidrug efflux pumps of the resistance-nodulation-division (RND) superfamily are major contributors to antibiotic resistance in

Indexed as

Anti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsDrug Resistance, Multiple, BacterialMembrane Transport ProteinsPseudomonas aeruginosaBinding SitesMicrobial Sensitivity TestsMutationSubstrate SpecificityAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsMembrane Transport Proteinsmolecular dockingmultidrug effluxPseudomonas aeruginosasubstrate specificitytransporter mechanism

Identifiers

PMID41543281
PMCPMC12910583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.