Evidence map›Paper›PMID 41543183›Full record

ReviewInternational journal of oncology2026

<p>Unveiling sex differences in pancreatic ductal adenocarcinoma: Current evidence and future directions (Review)</p>.

Sophie Rauschenberg, Elisabeth Orgler-Gasche, Didem Karakas Zeybek, Ivonne Regel, J-Matthias Löhr, Daniel Öhlund, Michael Günther, Lina Aguilera Munoz

Abstract readReview
In one paragraph

Review in International journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie Rauschenberg *Department for Internal Medicine I, University Hospital Halle (Saale), D-06120 Halle (Saale), Germany.
Elisabeth Orgler-Gasche *Department of Medicine II, University Hospital LMU Munich, D-81377 Munich, Germany.
Didem Karakas ZeybekGraduate School of Health, Medical Biotechnology, Acibadem University, 34752 Istanbul, Turkey.
Ivonne RegelDepartment of Medicine II, University Hospital LMU Munich, D-81377 Munich, Germany.
J-Matthias LöhrDepartment of Clinical Sciences, Karolinska Institute, 18288 Stockholm, Sweden.
Daniel ÖhlundDepartment of Diagnostics and Intervention (Oncology) and Wallenberg Centre of Molecular Medicine, Umeå University, 90187 Umeå, Sweden.
Michael Günther *Institute of General Pathology, Medical University of Innsbruck, A-6020 Innsbruck, Austria.
Lina Aguilera Munoz *Department of Pancreatology and Digestive Oncology, Beaujon University Hospital, 92110 Clichy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer‑related death worldwide in both men and women. While sex‑specific differences are increasingly recognized as critical determinants of health and disease, particularly in oncology, they remain markedly underexplored in PDAC. Emerging evidence suggests that sex differences influence numerous aspects of PDAC, including treatment response and prognosis. This knowledge gap represents a notable barrier to the development of effective, personalized therapeutic strategies for both sexes. The present review provides a comprehensive overview of the current knowledge on sex‑based differences in PDAC, encompassing epidemiology, risk factors, chemotherapy pharmacokinetics and toxicity, prognosis, therapeutic response, immune interactions, tumor microenvironment, tumor microbiota and molecular biomarkers.</p>.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsBiomarkers, TumorFemaleHumansMalePrognosisRisk FactorsSex CharacteristicsSex FactorsTumor MicroenvironmentBiomarkers, Tumorpancreatic cancerpancreatic ductal adenocarcinomaprecision oncologysex‑based medicinesex differences

Identifiers

PMID41543183
PMCPMC12823057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.