Evidence map›Paper›PMID 41543069›Full record

ArticleMicrobiology (Reading, England)2026

Hurdles to horizontal gene transfer: species-specific effects of synonymous variation and plasmid copy number determine antibiotic resistance phenotype.

Michael Finnegan, Caroline J Rose, Jeanne Hamet, Benjamin Prat, Stephanie Bedhomme

Abstract read
In one paragraph

Article in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael FinneganCEFE, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France.
Caroline J RoseCEFE, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France.
Jeanne HametCEFE, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France.
Benjamin PratCEFE, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France.
Stephanie BedhommeCEFE, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Could codon composition condition the immediate success and the orientation of horizontal gene transfer? Horizontal gene transfer represents a change in the genome of expression of the transferred gene, and experimental evidence has accumulated indicating that the codon composition of a sequence is an important determinant of its compatibility with the translation machinery of the genome in which it is expressed. This suggests that codon composition influences the phenotype and the fitness conferred by a transferred gene and thus the immediate success of the transfer. To directly test this hypothesis, we characterized the resistance conferred by synonymous variants of a gentamicin resistance gene in three bacterial species:

Indexed as

AcinetobacterDrug Resistance, BacterialEscherichia coliGene Transfer, HorizontalPlasmidsPseudomonas aeruginosaAnti-Bacterial AgentsCodonGene DosageGentamicinsPhenotypeSpecies SpecificityAnti-Bacterial AgentsCodonGentamicinsantibiotic resistancecodon usage preferenceshorizontal gene transfermulti-species approachsynonymous variation

Identifiers

PMID41543069
PMCPMC12811044

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.