Evidence map›Paper›PMID 41543053›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

"Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.

Tommaso Volpi, Mika Naganawa, Richard E Carson, Ansel T Hillmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Lower Muscarinic MBiological psychiatry · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tommaso VolpiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0002-5451-6710
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0002-4408-2621
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Ansel T HillmerDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0002-8105-1381

Funding

NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of NeurochemistryU01EB029811 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LI, HONGDI · 2020 to 2024
$10.0M
Neuroimaging Cholinergic Mechanisms of Fear Extinction in PTSDR01MH131551 · NIMH · YALE UNIVERSITY · PI Ansel Hillmer · 2023 to 2026
$2.4M
NIBIB NIH HHS U01 EB029811NIMH NIH HHS R01 MH131551
6 · The paper itself

Abstract

PET absolute quantification requires the metabolite-corrected plasma input function (

Indexed as

BrainModels, BiologicalPositron-Emission TomographyHumansImage Processing, Computer-AssistedKineticsRadiopharmaceuticalsRadiopharmaceuticalsclearance rate constant k2′Metabolite-corrected plasma input functionone-tissue compartment modelpseudo-reference regionsimplified reference tissue models

Identifiers

PMID41543053
PMCPMC12811094

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.