ArticleThe FEBS journal2026
Coenzyme A mitigates cystine-deprivation-induced ferroptosis by suppressing the iron-starvation response.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang
Abstract read
In one paragraphArticle in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Yunzhan LiDepartment of Cellular and Molecular Physiology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA.
Lei SangDepartment of Cellular and Molecular Physiology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA.
Min WangDepartment of Cellular and Molecular Physiology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA.
Qin LiDepartment of Cellular and Molecular Physiology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA.
Zekun LiDepartment of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, People's Republic of China.
Dongxiao SunDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.
Xiuchao WangDepartment of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, People's Republic of China.
Funding
Mitochondrial calcium signaling in pancreatic cancer metastasis and progressionR01CA256911 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Pankaj Kumar Singh, Shengyu Yang · 2022 to 2026
$3.2MRegulation of mitochondrial DNA homeostasis and neuroinflammation by Fascin in Alzheimer’s DiseaseRF1AG077451 · NIA · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI MA, YONGCHAO CHARLES, YANG, SHENGYU · 2022 to 2023
$2.3MA novel role of fascin in cancer metastasisR01CA233844 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YANG, SHENGYU · 2019 to 2023
$2.1MRegulation of mitochondrial DNA homeostasis and neuroinflammation by Fascin in Alzheimer’s DiseaseR01AG077451 · NIA · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Yongchao Charles Ma, Shengyu Yang · 2025 to 2026
$1.4MCongressionally Directed Medical Research Programs HT94252310348NCI NIH HHS R01 CA233844NCI NIH HHS R01 CA256911NCI NIH HHS R01CA256911NIA NIH HHS R01 AG077451NIA NIH HHS RF1 AG077451
6 · The paper itselfAbstract
The labile iron pool in the cell is required for ferroptosis, a form of regulated cell death resulting from excessive lipid peroxidation and membrane damage. Glutathione (GSH) is critical for lipid-peroxide scavenging, and cysteine is the rate-limiting amino acid in GSH synthesis. Cysteine metabolism intricately intertwines with iron metabolism, either directly by participating in assembly of the iron-sulfur cluster or indirectly through the pantothenate pathway and coenzyme A (CoA) synthesis. However, the regulation of iron homeostasis in cystine (Cys
Indexed as
Coenzyme ACystineFerroptosisIronAnimalsCysteineGlutathioneHumansIron-Sulfur ProteinsLipid PeroxidationOxidation-ReductionCoenzyme ACysteineCystineGlutathioneIronIron-Sulfur ProteinsCoenzyme Acysteinecystine‐deprivationferroptosisiron‐starvation responseiron–sulfur clusterpantothenate pathway
Identifiers
PMID41542927
PMCPMC12993722
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