Evidence map›Paper›PMID 41542771›Full record

ArticleThe Journal of clinical investigation2026

Elevated tRNA halves in olfactory epithelial cells of patients with schizophrenia.

Justin T Gumas, Megumi Shigematsu, Karin E Borgmann-Winter, Chang-Gyu Hahn, Yohei Kirino

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin T GumasComputational Medicine Center.
Megumi ShigematsuComputational Medicine Center.
Karin E Borgmann-WinterDepartment of Psychiatry and Human Behavior.
Chang-Gyu HahnDepartment of Psychiatry and Human Behavior.
Yohei KirinoComputational Medicine Center.

Funding

tRNA-derived non-coding RNAs in ASM function and in asthmaR01HL150560 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KIRINO, YOHEI · 2020 to 2023
$2.4M
Role of tRNA- and rRNA-derived RNAs in acute lung injuryR01HL175371 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Deepak A Deshpande, Yohei Kirino · 2024 to 2026
$1.9M
Biogenesis and function of cyclic phosphate-containing RNAsR35GM156496 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Yohei Kirino · 2025 to 2026
$858k
Role of proinflammatory tRNA-derived RNAs in asthmaR21AI130496 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI KIRINO, YOHEI · 2017 to 2018
$429k
Role of Toll-like receptor-induced short non-coding RNAs in innate immune responseR21AI151641 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI KIRINO, YOHEI · 2021 to 2022
$429k
Endogenous single-stranded RNA ligands for endosomal Toll-like receptorsR21AI171366 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI KIRINO, YOHEI · 2023 to 2024
$429k
NHLBI NIH HHS R01 HL150560NHLBI NIH HHS R01 HL175371NIAID NIH HHS R21 AI130496NIAID NIH HHS R21 AI151641NIAID NIH HHS R21 AI171366NIGMS NIH HHS R35 GM156496
6 · The paper itself

Abstract

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

Indexed as

Epithelial CellsOlfactory MucosaRNA, TransferSchizophreniaHumansRNA, TransferCell biologyPublic HealthRNA processingSchizophrenia

Identifiers

PMID41542771
PMCPMC12807459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.