Evidence map›Paper›PMID 41542756›Full record

ArticleBioconjugate chemistry2026

Fluorogenic Imaging Enables the Identification of Phosphoramidate Antibody-Drug Conjugate Linkers.

Pradeep Shrestha, Veera V Shivaji R Edupuganti, Connor Wang, Nimit L Patel, Lai Thang, Simone Difilippantonio, Martin J Schnermann

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pradeep ShresthaChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0003-4166-966X
Veera V Shivaji R EdupugantiChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0002-1548-8032
Connor WangChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
Nimit L PatelSmall Animal Imaging Program, FNCLR, Leidos Biomedical Research Inc., Frederick, Maryland 21702, United States.
Lai ThangAnimal Research Technical Support, FNLCR, Leidos Biomedical Research, Inc., Frederick, Maryland 21702, United States.
Simone DifilippantonioAnimal Research Technical Support, FNLCR, Leidos Biomedical Research, Inc., Frederick, Maryland 21702, United States.
Martin J SchnermannChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0002-0503-0116

Funding

Synthesis and evaluation of small-molecule imaging agentsZIABC011506 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNERMANN, MARTIN · 2013 to 2025
$12.1M
Near-IR Photorelease Chemistry: Discovery and ApplicationsZIABC011564 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNERMANN, MARTIN · 2014 to 2025
$9.5M
Intramural NIH HHS ZIA BC011506Intramural NIH HHS ZIA BC011564NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Modular, tunable linker chemistries that are stable in circulation yet selectively cleaved are needed to realize the therapeutic potential of antibody-drug conjugates (ADCs). Near-infrared (NIR) fluorogenic imaging using norcyanine carbamate (CyBam) probes can quantitatively compare ADC linkers across

Indexed as

AmidesFluorescent DyesImmunoconjugatesOptical ImagingPhosphoric AcidsAnimalsCell Line, TumorHumansMiceOligopeptidesPanitumumabAmidesFluorescent DyesImmunoconjugatesmonomethyl auristatin EOligopeptidesPanitumumabphosphoramidic acidPhosphoric Acids

Identifiers

PMID41542756
PMCPMC13227547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.