Evidence map›Paper›PMID 41542740›Full record

ArticleAnnals of neurology2026

Clinical and Biological Determinants of Longitudinal Cognitive Function in Patients With GBA1 Variants and Subthalamic Deep Brain Stimulation.

Moritz A Loeffler, Philipp Klocke, Isabel Wurster, Stefanie Lerche, Idil Cebi, Thomas Gasser, Alireza Gharabaghi, Kathrin Brockmann, Daniel Weiss

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In one paragraph

Article in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Does genetic testing remain relevant in advanced Parkinson's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Moritz A LoefflerCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-0267-2762
Philipp KlockeCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
Isabel WursterCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
Stefanie LercheCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-5508-004X
Idil CebiCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
Thomas GasserCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
Alireza GharabaghiInstitute for Neuromodulation and Neurotechnology, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-9782-5281
Kathrin BrockmannCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-7515-8596
Daniel WeissCentre for Neurology, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-0447-7132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWhether cognitive decline in patients with Parkinson's disease (PD) carrying GBA1 variants is accelerated after subthalamic deep brain stimulation (STN-DBS) remains controversial. Clarifying long-term cognitive outcomes is essential for informed decision making.

methodsWe assembled matched cohorts of patients carrying GBA1 variants with STN-DBS (PD

resultsThere was no significant difference in cognitive decline between PD

interpretationGBA1 variant carriers meeting general STN-DBS indication criteria did not show accelerated cognitive decline in the presence of STN-DBS. In addition, exploratory predictors of dementia could support counseling of DBS candidates. ANN NEUROL 2026;99:976-988.

Indexed as

CognitionCognitive DysfunctionDeep Brain StimulationGlucosylceramidaseParkinson DiseaseAgedBiomarkersCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedSubthalamic NucleusBiomarkersGBA protein, humanGlucosylceramidase

Identifiers

PMID41542740
PMCPMC13011785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.