Evidence map›Paper›PMID 41542713›Full record

SynthesisComprehensive reviews in food science and food safety2026

Trends on Strategies for Mitigation of Antibiotic Residues in Milk and Dairy Products Based on Scientometric Analysis and Systematic Review.

Emelda Orlando Simbine-Ribisse, Wilma Custódio Fumo, Eugénio da Piedade Edmundo Sitoe, Patrícia Aparecida de Campos Braga, Cristiano João Macuamule, Adriana Pavesi Arisseto Bragotto

Abstract readSystematic Review
In one paragraph

Synthesis in Comprehensive reviews in food science and food safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emelda Orlando Simbine-RibisseDepartment of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-8038-8353
Wilma Custódio FumoDepartment of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Eugénio da Piedade Edmundo SitoeDepartment of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0003-3335-6591
Patrícia Aparecida de Campos BragaDepartment of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Cristiano João MacuamuleSection of Pharmacology and Toxicology, Department of Public and Animal Health, Veterinary Faculty, Universidade Eduardo Mondlane, Maputo, Mozambique.
Adriana Pavesi Arisseto BragottoDepartment of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.

Funding

Organization for Women in Science for the Developing World (OWSD) No.3240318610
6 · The paper itself

Abstract

The presence of antibiotic residues (ARs) in milk poses a significant challenge to public health and the dairy industry. This study presents the research trends on strategies to mitigate ARs in milk and dairy products, combining scientometric and systematic review approaches. Following the PRISMA guidelines, data from Web of Science, ScienceDirect, PubMed, Embase, AGRICOLA, and CAS Abstract yielded 49 original articles. Geographical analysis revealed a heterogeneous distribution, with Spain as the leading contributor. The analysis showed that heat treatment is the most studied mitigation strategy, reflecting its widespread industrial implementation. Crucially, a clear trend indicates the growth of emerging nonthermal technologies, such as pulsed electric field (PEF) and ozonation, driven by the need to preserve the nutritional and sensory attributes of milk. The most studied antibiotics belong to the tetracycline and penicillin classes, with oxytetracycline being most frequently investigated, followed by penicillin, tetracycline, ampicillin, chlortetracycline, cloxacillin, and amoxicillin. The findings confirm that no single strategy is universally effective. The results indicate that the future of ARs mitigation lies in the development of synergistic and combined approaches to achieve industrially viable, cost-effective protocols that preserve product quality. This study highlights the need for future research focused on selective technologies and the assessment of by-product toxicity, alongside the regulatory aspects for the application of these technologies.

Indexed as

Anti-Bacterial AgentsDairy ProductsDrug ResiduesFood ContaminationMilkAnimalsAnti-Bacterial Agentsantibiotic reductionbibliometricdairy productsnonthermalthermal

Identifiers

PMID41542713
PMCPMC12809382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.