ArticlemedRxiv : the preprint server for health sciences2026
Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.
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165 authors.
Nigussie T SharewDiscipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.ORCID 0000-0002-6443-6992
Scott R ClarkDiscipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.
Simon HartmannDiscipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Franziska DegenhardtInstitute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales, Australia.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, San Diego, California.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Bárbara AriasUnitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain.
Fasil Tekola-AyeleEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Perú.
Roland HaslerDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Hélène Richard-LepourielDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Nader PerroudDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, San Diego, California.
Frank BellivierInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Antonio BenabarreBipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Susanne BengesserDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Armin BirnerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Cynthia Marie-ClaireInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Pablo CervantesNeuromodulation Unit, McGill University Health Centre, Montreal, Quebec, Canada.
Hsi-Chung ChenDepartment of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonHuman Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland.
Nina DalknerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Bruno ÉtainInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Stephane JamainUniv Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.
Andreas J ForstnerInstitute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.
Louise FrisenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.
Sébastien GardPôle de Psychiatrie Générale Universitaire, Hôpital Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Andreas J FallgatterUniversity Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany.
Sophia StegmaierUniversity Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany.
Thomas EthoferDepartment of General Psychiatry, University of Tübingen, Tübingen, Germany.
Silvia BiereDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Kristiyana PetrovaDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Ceylan SchusterDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Maria HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Mojtaba Oraki KohshourInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Sabrina K SchauppInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Thomas VoglInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Ion-George AnghelescuDepartment of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany.
Volker AroltInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Detlef E DietrichAMEOS Clinical Center Hildesheim, Hildesheim, Germany.
Christian FiggeKarl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.
Markus JägerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Fabian U LangDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Georg JuckelDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Carsten KonradDepartment of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
Jens ReimerDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Max SchmaußDepartment of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.
Carsten SpitzerDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.
Martin von HagenClinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Jörg ZimmermannPsychiatrieverbund Oldenburger Land GmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.
Till F M AndlauerDepartment of Neurology, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
Andre FischerGerman Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.
Felix BermpohlDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Philipp RitterDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany.
Silke MaturaDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Anna GryaznovaInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Irina FalkenbergDepartment of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Cüneyt YildizDepartment of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Julia SchmidtInstitute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Marius KochInstitute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Kathrin GadeDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Sarah TrostDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Ida S HaussleiterDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Martin LambertDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anja C RohenkohlDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Vivien KraftDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Paul GrofMood Disorders Center of Ottawa, Ottawa, Ontario, Canada.
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland.
Stefan HermsInstitute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.
Esther JiménezBipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France.
Layla KassemDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Po-Hsiu KuoDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Saitama, Japan.
John KelsoeDepartment of Psychiatry, University of California San Diego, San Diego, California.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Ewa Ferensztajn-RochowiakDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.
Barbara KönigDepartment of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Ichiro KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Gonzalo LajeDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Mikael LandénInstitute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Marion LeboyerInserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France.
Susan G LeckbandOffice of Mental Health, VA San Diego Healthcare System, San Diego, California.
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.
Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.
Michael J McCarthyDepartment of Psychiatry, University of California San Diego, San Diego, California.
Susan L McElroyDepartment of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, Ohio.
Francesc ColomMental Health Research Group, Hospital del Mar Medical Research Institute (IMIM)-Hospital del Mar, Barcelona, Catalonia, Spain.
Vincent MillischerDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Marina MitjansCIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Palmiero MonteleoneNeurosciences Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, San Diego, California.
Markus M NöthenInstitute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.
Tomas NovákNational Institute of Mental Health, Klecany, Czechia.
Claire O'DonovanDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Norio OzakiDepartment of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany.
Claudia PisanuDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Peter R SchofieldNeuroscience Research Australia, Sydney, New South Wales, Australia.
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, San Diego, California.
Katzutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Christian SimhandlBipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czechia.
Mario MajDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Eduard VietaBipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Julia VeehInstitute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Biju ViswanathDepartment of Psychiatry, National Institute of Mental Health and Neuroscience, Bangalore, India.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Adam WrightDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, New South Wales, Australia.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Philip B MitchellDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, New South Wales, Australia.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Bernhard T BauneDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
Klaus Oliver SchubertDiscipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.
Azmeraw T AmareDiscipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.ORCID 0000-0002-7940-0335
Funding
The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1MMapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0MCollaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9MCOLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059556 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI SCHEFTNER, WILLIAM A · 1998 to 2007
$1.6MHuman Genetics of Addiction: A Study of Common and Specific FactorsK02DA021237 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2007 to 2011
$567kIntramural NIH HHS Z01 MH002810NCI NIH HHS P01 CA089392NIDA NIH HHS K02 DA021237NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068
Abstract
Background: The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder (BD) remains limited. Aim: To enhance prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes implicated in lithium response and/or BD aetiology. Methods: We analysed data collected from BD patients who had received lithium treatment for at least six months and participated in the International Consortium on Lithium Genetics (ConLi Results: The mt-PGS explained 5.07% (continuous outcome) to 9.02% (categorical outcome) of the interindividual variability in lithium responsiveness. Classification accuracy (AUC) for the categorical outcome was 68.13% (95% CI: 64.86, 71.77). Of the five clusters, the PGSs for clinical lithium exemplar phenotypes were most strongly associated with lithium responsiveness, accounting for 2.97%-6.20% of its variability. Conclusions: By integrating polygenic scores for multiple relevant phenotypes, predictive accuracy for lithium response improved up to nine-fold compared to single-trait methods. Future research incorporating larger, more diverse populations and combining genetic scores with clinical data holds promise for further enhancing prediction and advancing clinical implementation.
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LithiumMachine learningMulti-traitPharmacogenomicspolygenic scorePsychiatry
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