Evidence map›Paper›PMID 41542694›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Race, Ethnicity and Their Implication on Bias in Large Language Models.

Shiyue Hu, Ruizhe Li, Yanjun Gao

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shiyue HuUniversity of Colorado Anschutz.
Ruizhe LiUniversity of Aberdeen.ORCID 0000-0003-2512-845X
Yanjun GaoUniversity of Colorado Anschutz.ORCID 0000-0002-9341-7360

Funding

Developing and Evaluating Multi-Modal Clinical Diagnostic Reasoning Models for Automated Diagnosis GenerationR00LM014308 · NLM · UNIVERSITY OF COLORADO DENVER · PI Yanjun Gao · 2024 to 2026
$726k
NLM NIH HHS R00 LM014308
6 · The paper itself

Abstract

Large language models (LLMs) increasingly operate in high-stakes settings including healthcare and medicine, where demographic attributes such as race and ethnicity may be explicitly stated or implicitly inferred from text. However, existing studies primarily document outcome-level disparities, offering limited insight into internal mechanisms underlying these effects. We present a mechanistic study of how race and ethnicity are represented and operationalized within LLMs. Using two publicly available datasets spanning toxicity-related generation and clinical narrative understanding tasks, we analyze three open-source models with a reproducible interpretability pipeline combining probing, neuron-level attribution, and targeted intervention. We find that demographic information is distributed across internal units with substantial cross-model variation. Although some units encode sensitive or stereotype-related associations from pretraining, identical demographic cues can induce qualitatively different behaviors. Interventions suppressing such neurons reduce bias but leave substantial residual effects, suggesting behavioral rather than representational change and motivating more systematic mitigation.

Identifiers

PMID41542694
PMCPMC12803294

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.