Evidence map›Paper›PMID 41542691›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Diagnostic Potential for IgM Antibody Detection by the DPP Syphilis TnT Assay in Neonates at Risk for Congenital Syphilis.

Irene A Stafford, Lierni Ugartemendia Ugalde, Laura M Goetzl, Analuisa Mosqueda, Sabrina DaCosta, Dhammika Gunasekera, Mark Rivieccio, Javan Esfandiari, Konstantin P Lyashchenko

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Irene A StaffordDepartment of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030.ORCID 0000-0002-2803-7329
Lierni Ugartemendia UgaldeGoetzl Lab. Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030.
Laura M GoetzlDepartment of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal-Fetal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030.
Analuisa MosquedaDepartment of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030.
Sabrina DaCostaDepartment of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030.
Dhammika GunasekeraResearch and Development (R&D), Chembio Diagnostics, Inc., Medford, NY, 11763.
Mark RivieccioResearch and Development (R&D), Chembio Diagnostics, Inc., Medford, NY, 11763.
Javan EsfandiariChembio Diagnostics, Inc., Medford, NY, 11763.
Konstantin P LyashchenkoResearch and Development (R&D), Chembio Diagnostics, Inc., Medford, NY, 11763.ORCID 0000-0002-0200-8255

Funding

Modernizing Perinatal Syphilis TestingR01HD108201 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Irene A. Stafford · 2023 to 2026
$2.7M
NICHD NIH HHS R01 HD108201
6 · The paper itself

Abstract

Background: Neonatal IgM antibodies reflect an in-utero immune response to Methods: Conducted from May 2023 to May 2025, this study tested neonatal serum samples from infants born to mothers with syphilis using the DPP Syphilis TnT RUO POC assay, which reports treponemal and nontreponemal IgM levels as relative light units (RLU). Neonates were classified as Results: Twenty-two maternal-neonatal dyads were included. Mean treponemal IgM levels rose with CS severity, peaking in the high-risk group ( Conclusion: The DPP Syphilis TnT RUO POC assay's treponemal IgM levels discriminated CS risk categories effectively and may supplement current algorithms to improve neonatal CS stratification.

Indexed as

Congenital syphilisnontreponemalsexually transmitted infectionstreponemal

Identifiers

PMID41542691
PMCPMC12803397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.