Evidence map›Paper›PMID 41542677›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Maternal Opioids Downregulate Adiponectin Receptor Signaling and Alter Growth in Offspring: Pilot Study.

Elizabeth Yen, Kiran Singh, Marissa Chow, Francesca Carasi-Schwartz, Mario Cordova, Tomoko Kaneko-Tarui, Emily Brew, Taysir Mahmoud, Pratik Reddy, Angie Mae Rodday and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Elizabeth YenWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID 0000-0002-5916-3299
Kiran SinghWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.
Marissa ChowWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID 0009-0009-2696-8056
Francesca Carasi-SchwartzWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.
Mario CordovaTufts Medicine Pediatrics, Boston, MA, USA.
Tomoko Kaneko-TaruiWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID 0000-0001-5463-1551
Emily BrewWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.
Taysir MahmoudWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID 0000-0001-9225-6115
Pratik ReddyTufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.ORCID 0009-0008-9771-4574
Angie Mae RoddayTufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-8671-3401
Jill MaronWomen and Infants Hospital, Providence, RI, USA.ORCID 0000-0002-1071-8468
Jonathan M DavisTufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-1809-2295
Perrie O'Tierney-GinnWoman, Mother + Baby (WoMB) Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID 0000-0001-5752-4874

Funding

Tufts Clinical and Translational Science Institute (Clinical Trial Design Labs Supplement)UM1TR004398 · NCATS · TUFTS UNIVERSITY BOSTON · PI Harry P. Selker · 2023 to 2026
$44.5M
Sex-specific Impact of Prenatal Opioids on Brain Reward Signaling and Neonatal Feeding RegulationK23DA056847 · NIDA · TUFTS MEDICAL CENTER · PI YEN, ELIZABETH · 2023 to 2025
$573k
NCATS NIH HHS UM1 TR004398NIDA NIH HHS K23 DA056847
6 · The paper itself

Abstract

Opioid use disorder (OUD) has been linked to cardiometabolic diseases in adults through reductions in adiponectin-an adipocytokine with insulin-sensitizing effects. Opioid use during pregnancy dysregulates neonatal growth and may predispose to adult-onset diseases, but the impact of maternal OUD on neonatal adiponectin has not been studied. We hypothesize that maternal OUD also reduces adiponectin level in offspring (primary outcome) and alters growth (secondary outcome). To test our hypothesis, we conducted a prospective, observational pilot study and compared the expression of salivary adiponectin receptor 1/

Indexed as

adiponectinadipositybody compositiondevelopmental programmingfat-free massfat massneonatal abstinence syndromesex-specific effects

Identifiers

PMID41542677
PMCPMC12803365

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.