Evidence map›Paper›PMID 41542676›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Antidepressant drugs have pharmacological- and time-dependent effects on reinforcement learning in healthy volunteers: An 8 weeks randomized double-blind placebo-controlled study.

Lucie Berkovitch, Fabien Vinckier, Alexandre Salvador, Mathias Pessiglione, John F W Deakin, Gerard R Dawson, Catherine J Harmer, Guy M Goodwin, Raphaël Gaillard

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucie BerkovitchUniversité Paris Cité, F-75006 Paris, France.
Fabien VinckierUniversité Paris Cité, F-75006 Paris, France.
Alexandre SalvadorUniversité Paris Cité, F-75006 Paris, France.
Mathias PessiglioneMotivation, Brain & Behavior (MBB) lab, Paris Brain Institute, F-75013, Paris, France.
John F W DeakinNeuroscience and Psychiatry Unit, The University of Manchester, Manchester, UK.
Gerard R DawsonP1vital LTD, Manor House, Howbery Business Park, Wallingford, UK.
Catherine J HarmerUniversity Department of Psychiatry, Warneford Hospital, Oxford, UK.
Guy M GoodwinUniversity Department of Psychiatry, Warneford Hospital, Oxford, UK.
Raphaël GaillardUniversité Paris Cité, F-75006 Paris, France.

Funding

A Translational and Neurocomputational Evaluation of a D1R Partial Agonist for SchizophreniaU01MH121766 · NIMH · YALE UNIVERSITY · PI KRYSTAL, JOHN H. · 2019 to 2022
$11.8M
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCDR01MH116038 · NIMH · YALE UNIVERSITY · PI ANTICEVIC, ALAN, PITTENGER, CHRISTOPHER JOHN · 2019 to 2023
$3.7M
NIMH NIH HHS R01 MH116038NIMH NIH HHS U01 MH121766
6 · The paper itself

Abstract

Isolating specific cognitive effects of antidepressant drugs is crucial to develop targeted and individualized treatment selection in psychiatry. In this double-blind, placebo-controlled study in healthy controls, we used computational modeling to characterize the cognitive effects of two classes of drugs for depression, escitalopram, a typical SSRI which increases serotonergic transmission, and agomelatine, which activates melatonin receptors and antagonizes 5-HT

Indexed as

Antidepressantscognitive neurosciencecomputational psychiatryhealthy volunteersreinforcement learning

Identifiers

PMID41542676
PMCPMC12803370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.