Evidence map›Paper›PMID 41542650›Full record

ArticlebioRxiv : the preprint server for biology2026

Placental Insulin-like Growth Factor 1 Insufficiency Drives Neurodevelopmental Disorder-Relevant Behavioral Changes with Sex-Specific Vulnerabilities.

Annemarie J Carver, Faith M Fairbairn, Robert J Taylor, Benjamin W Q Hing, Amrita Gajmer, Regan T Fair, Hanna E Stevens

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Annemarie J CarverInterdisciplinary Graduate Program in Genetics, University of Iowa, IA, USA.ORCID 0000-0003-1865-0370
Faith M FairbairnDepartment of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA.ORCID 0009-0004-0991-2337
Robert J TaylorDepartment of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA.
Benjamin W Q HingDepartment of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA.
Amrita GajmerDepartment of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA.
Regan T FairIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, IA, USA.
Hanna E StevensInterdisciplinary Graduate Program in Genetics, University of Iowa, IA, USA.ORCID 0000-0002-3906-0786

Funding

University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1M
Predoctoral Training Program in GeneticsT32GM145441 · NIGMS · UNIVERSITY OF IOWA · PI Josep M Comeron, DANIEL F EBERL · 2022 to 2026
$1.5M
Beginning and Early Stage Translational (BEST) ResearchersR25TR004393 · NCATS · UNIVERSITY OF IOWA · PI Donna Ann Santillan · 2023 to 2026
$432k
NCATS NIH HHS R25 TR004393NICHD NIH HHS P50 HD103556NIGMS NIH HHS T32 GM008629NIGMS NIH HHS T32 GM145441
6 · The paper itself

Abstract

Preterm birth, placental insufficiency, and other perinatal adversities lead to the loss of placental support including critical hormones, such as Insulin-like growth factor 1 (IGF1), required for neurodevelopment. Decreased IGF1 and preterm birth are associated with neurodevelopmental disorder risk, including autism spectrum disorder. Whether placental

Indexed as

Autism Spectrum DisorderInsulin-like Growth Factor 1NeurodevelopmentNeuroplacentologyPlacentaPreterm Birth

Identifiers

PMID41542650
PMCPMC12803038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.