Evidence map›Paper›PMID 41542648›Full record

ArticlebioRxiv : the preprint server for biology2026

Dual NLRC4 and non-canonical inflammasome signaling drives human GSDMD-mediated killing of

Mateusz Szczerba, Marcia B Goldberg

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mateusz SzczerbaCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6820-8076
Marcia B GoldbergCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-4266-9733

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Human NLRP11 function in non-canonical inflammasome activation by bacterial pathogen LPSR01AI173030 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 2023 to 2026
$2.1M
Control of intracellular Shigella in human macrophages.F32AI188955 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SZCZERBA, MATEUSZ · 2025 to 2025
$80k
NIAID NIH HHS F32 AI188955NIAID NIH HHS R01 AI173030NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

Macrophages internalize and kill bacteria and thus are crucial for clearing bacterial infections. Although macrophage killing of some intracellular bacteria requires inflammasomes, the specific mechanisms of inflammasome-dependent killing are incompletely understood. Here we show that, upon infection with an intracellular pathogen

Identifiers

PMID41542648
PMCPMC12803174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.