ArticlebioRxiv : the preprint server for biology2025
Need-selective gating of dopamine neuron cue responses by real and virtual hunger.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
The midbrain dopamine system is important for linking reward-predictive cues to learning and motivation. Here we investigated how dopamine neuron responses to food and water cues are modulated by changes in internal state. We developed a flexible cued-approach task that allowed us to examine behavioral and neural responses to both food- and water-predictive cues within the same recording session. We found that overlapping subsets of dopamine neurons respond to food and water cues, but that the magnitude of these responses is gated in a need-specific way. Stimulation of hunger-promoting AgRP neurons amplified dopamine neuron responses to food cues, but not water cues, and the magnitude of these responses exceeded those observed in natural hunger. These findings indicate that changes in internal state modulate, in a need-appropriate way, the responses of a common set of dopamine neurons to environmental signals of food and water availability.
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