Evidence map›Paper›PMID 41542633›Full record

ArticlebioRxiv : the preprint server for biology2026

Diverse bacterial pattern recognition receptors sense the conserved phage proteome.

Hyunbin Lee, Sofia Luengo-Woods, Jianxiu Zhang, Kira S Makarova, Yuri I Wolf, Collin Chiu, Simone A Evans, Junyi Chen, Haopeng Xiao, Liang Feng and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Hyunbin LeeDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0006-1911-435X
Sofia Luengo-WoodsDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0004-6209-4783
Jianxiu ZhangDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1864-7510
Kira S MakarovaComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-8174-2844
Yuri I WolfComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-0247-8708
Collin ChiuDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Simone A EvansDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4975-8747
Junyi ChenDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-7453-6623
Haopeng XiaoDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-4166-647X
Liang FengDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.
Eugene V KooninComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-3943-8299
Alex GaoDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3579-0327

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
Genetics and Developmental Biology Training ProgramT32GM141828 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER, Gavin J Sherlock · 2022 to 2026
$2.6M
Molecular mechanisms of mitochondrial membrane transport systems in cellular energeticsR35GM153424 · NIGMS · STANFORD UNIVERSITY · PI Liang Feng · 2024 to 2026
$2.5M
NIGMS NIH HHS R35 GM153424NIGMS NIH HHS T32 GM007276NIGMS NIH HHS T32 GM141828NIGMS NIH HHS U24 GM129541
6 · The paper itself

Abstract

Recognition of foreign molecules inside cells is critical for immunity in all domains of life. Proteins of the STAND NTPase superfamily, including eukaryotic nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), play a central role in this process. In bacteria and archaea, although several STAND NTPase families have been reported to sense phage proteins, their functional diversity remains largely unexplored. Here, we conducted a systematic phylogenetic analysis of prokaryotic STAND NTPases and identified at least 90 structurally distinct families associated with antiviral defense. We first show that the uncharacterized Avs7 family recognizes the major capsid protein (MCP) of tailed phages. Three cryo-EM structures of

Identifiers

PMID41542633
PMCPMC12803255

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.