Evidence map›Paper›PMID 41542600›Full record

ArticlebioRxiv : the preprint server for biology2026

Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure.

Le Gia Cat Pham, Kurrim Gilliard, Frances Jourd'heuil, Sarahann Mistretta, John J Schwarz, Harold A Singer, David Jourd'heuil

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Le Gia Cat PhamDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Kurrim GilliardDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Frances Jourd'heuilDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Sarahann MistrettaDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
John J SchwarzDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Harold A SingerDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
David Jourd'heuilDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.

Funding

Role of cytoglobin in promoting smooth muscle cell survival during maladaptive vascular remodelingR01HL142807 · NHLBI · ALBANY MEDICAL COLLEGE · PI JOURD'HEUIL, DAVID · 2019 to 2021
$1.2M
NHLBI NIH HHS R01 HL142807
6 · The paper itself

Abstract

Hypertension-mediated left ventricular hypertrophy and cardiac fibrosis often precede heart failure. Recent studies indicate that cytoglobin (Cygb), a globin expressed in the vasculature, increases systemic blood pressure. The present work aims to determine the role of Cygb in angiotensin II (Ang II)-induced cardiac hypertrophy and fibrosis in the mouse. Methods: Males and females global Cygb knockout ( Results: Conclusions: Our findings indicate that Cygb plays a protective role in the mouse heart during Ang II-induced cardiac stress. This is the first study detailing the function of Cygb in the heart as a regulator of cardiac hypertrophy. This study also reveals a role for Cygb in regulating cardiac fibroblast activation by Ang II.

Indexed as

fibroblastsfibrosisheart failurehemoglobinsmyofibroblasts

Identifiers

PMID41542600
PMCPMC12803031

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.