Evidence map›Paper›PMID 41542594›Full record

ArticlebioRxiv : the preprint server for biology2026

Develop a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rationale adjuvant selection.

Miranda McCarty, Sergio A Hernández, Jill Malfetano, Ana Carolina Leão, Maria Jose Villar, Xiuli Yang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Ulrich Strych and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Miranda McCartyDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Sergio A HernándezDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Jill MalfetanoDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Ana Carolina LeãoDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Maria Jose VillarDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Xiuli YangDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States.
Yi-Lin ChenDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Jungsoon LeeDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Zhuyun LiuDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Ulrich StrychDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Maria Elena BottazziDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Utpal PalDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States.
Klemen StrleDepartment of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston; MA, USA.
Wen-Hsiang ChenDepartment of Pediatrics (Tropical Medicine), National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Yi-Pin LinDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.ORCID 0000-0002-5240-2031

Funding

Multivalent Tick-Microbe targeted Lyme disease vaccinesR01AI154542 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL, SCHNELL, MATTHIAS JOHANNES · 2020 to 2025
$3.5M
Microbial Determinants of Excessive Inflammation and Severe Lyme DiseaseR01AI181904 · NIAID · TUFTS UNIVERSITY BOSTON · PI STRLE, KLEMEN · 2025 to 2025
$3.3M
Immunomodulatory mechanisms of wild bird reservoir hosts that facilitate persistence of Lyme disease bacteriaR01AI181746 · NIAID · TUFTS UNIVERSITY BOSTON · PI Yi-Pin Lin · 2024 to 2026
$2.5M
Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
NIAID NIH HHS R01 AI154542NIAID NIH HHS R01 AI181746NIAID NIH HHS R01 AI181904NIAID NIH HHS R21 AI144891
6 · The paper itself

Abstract

Rational adjuvant selection is a systematic approach based on adjuvant-mediated immunomodulation to identify safe vaccine regimens that enhance protective immunity. Transmitted through ticks and caused by the bacterium

Indexed as

AdjuvantBorreliaCspZLyme diseaseVaccine

Identifiers

PMID41542594
PMCPMC12803166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.