Evidence map›Paper›PMID 41542588›Full record

ArticlebioRxiv : the preprint server for biology2026

The modular nature of long-association pathways in the human brain.

Chiara Maffei, Marina R Celestine, Ting Gong, Robert Jones, Evan Dann, Julia Lehman, Jean Augustinack, Hui Wang, Suzanne N Haber, Anastasia Yendiki

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiara MaffeiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Marina R CelestineDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Ting GongAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Robert JonesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Evan DannAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Julia LehmanDepartment of Pharmacology & Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Jean AugustinackAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Hui WangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Suzanne N HaberDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Anastasia YendikiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

Funding

The neural network of OCD, linking NHP and human studiesP50MH106435 · NIMH · UNIVERSITY OF ROCHESTER · PI Suzanne N Haber · 2015 to 2026
$28.9M
BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Bridging Diffusion MRI and Chemical Tracing for Validation and Inference of Fiber ArchitecturesR01NS119911 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YENDIKI, ANASTASIA · 2021 to 2024
$2.6M
Multimodal mapping of the neurocircuitry of the human prefrontal cortexR01EB021265 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI YENDIKI, ANASTASIA · 2016 to 2019
$2.0M
Mapping Human Neurocircuitry Across Scales with Diffusion MRI and Optical ImagingR01NS127353 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Anastasia Yendiki · 2024 to 2026
$1.9M
NIBIB NIH HHS R01 EB021265NIMH NIH HHS P50 MH106435NINDS NIH HHS R01 NS119911NINDS NIH HHS R01 NS127353NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

Human brain functions are organized within large-scale networks, yet the long-range structural pathways that support them remain only partly understood. Diffusion MRI tractography has enabled non-invasive mapping of these connections but its low resolution has also contributed to a view of white matter association bundles as monolithic entities linking distant cortical regions. This contrasts with anatomical studies in non-human primates and humans, which show these bundles act as conduits for complex systems of short- and long-range projections. Here we investigate the dorsal branch of the superior longitudinal fasciculus (SLF-I), the proposed structural backbone of the dorsal attention network, whose anatomy in humans is debated. Using anatomic tracing, polarization-sensitive optical coherence tomography, and

Identifiers

PMID41542588
PMCPMC12803271

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.