Evidence map›Paper›PMID 41542581›Full record

ArticlebioRxiv : the preprint server for biology2026

Proteomics Defines Shared and Divergent Alterations in the Right Atrium and Right Ventricle in Porcine Right Heart Failure.

Sally E Prins, Jacob Sternbach, Jenna B Mendelson, Todd Markowski, LeeAnn Higgins, John P Carney, Walt Tollison, Gaurav Choudhary, Kurt W Prins

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sally E PrinsGazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina.
Jacob SternbachLillehei Heart Institute, Cardiovascular Division, Department of Medicine, University of Minnesota.
Jenna B MendelsonDepartment of Integrative Biology and Physiology, University of Minnesota.ORCID 0000-0002-8229-385X
Todd MarkowskiCenter for Metabolomics and Proteomics, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota.
LeeAnn HigginsCenter for Metabolomics and Proteomics, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota.
John P CarneyExperimental Surgical Services, Department of Surgery, University of Minnesota.
Walt TollisonExperimental Surgical Services, Department of Surgery, University of Minnesota.
Gaurav ChoudharyVascular Research Laboratory Providence VA Medical Center Providence Rhode Island USA, Division of Cardiology, Department of Medicine Alpert Medical School of Brown University.
Kurt W PrinsGazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina.ORCID 0000-0002-0364-6742

Funding

GP130 Antagonism in Porcine RV Pressure OverloadR01HL162927 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$3.3M
Multi-scale Investigation of Sex Differences in Right Ventricular Function via Estrogen-Microtubule InteractionsR01HL158795 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$2.8M
Role of Endothelial Anoctamin-1 in Pulmonary Arterial HypertensionR01HL148727 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV · 2019 to 2022
$1.6M
Role of Mitochondrial c-Src in Right Ventricular Dysfunction in Pulmonary HypertensionR01HL169456 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI Gaurav Choudhary, Peng Zhang · 2024 to 2026
$1.3M
Mechanisms of Large Animal RV DysfunctionF31HL170585 · NHLBI · UNIVERSITY OF MINNESOTA · PI MENDELSON, JENNA BLAIR · 2024 to 2025
$71k
NHLBI NIH HHS F31 HL170585NHLBI NIH HHS R01 HL148727NHLBI NIH HHS R01 HL158795NHLBI NIH HHS R01 HL162927NHLBI NIH HHS R01 HL169456
6 · The paper itself

Abstract

Right heart failure is due to both right atrial and right ventricular dysfunction. While the two chambers are distinct, the proteomic response to pressure overload is undefined. Here, we used quantitative proteomics to evaluate changes in both chambers in pulmonary artery banded pigs. We found common alterations in oxidative phosphorylation, ribosome regulation, integrin-mediated adhesion, and glycolysis enzymes. However, the right atrium had more pronounced deficits in the TCA cycle and branched chain amino acid metabolism. Thus, these data highlight metabolic pathways that could be evaluated to selectively enhance right atrial function.

Identifiers

PMID41542581
PMCPMC12803194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.